loading...| Preferred Name |
Epoetin Alfa |
|
| Synonyms |
epoetin alfa Epoetin Alfa Epoetin alfa Epoetin alfa-epbx EPO Epogen Eprex Procrit Retacrit |
|
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine human erythropoietin (EPO). Produced primarily by cells of the peritubular capillary endothelium of the kidney in response to hypoxia, circulating EPO binds to EPO receptors on the surface of committed erythroid progenitors in the bone marrow resulting in their replication and maturation into functional erythrocytes. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2695 |
|
| Accepted_Therapeutic_Use_For |
anemia due to chronic kidney disease (CKD); reduction of allogeneic red blood cell transfusions |
|
| ALT_DEFINITION |
A substance that is made in the laboratory and stimulates the bone marrow to make red blood cells. It is a type of antianemic and a type of recombinant human erythropoietin. |
|
| CAS_Registry |
113427-24-0 |
|
| code |
C2695 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP HemOnc |
|
| DEFINITION |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine human erythropoietin (EPO). Produced primarily by cells of the peritubular capillary endothelium of the kidney in response to hypoxia, circulating EPO binds to EPO receptors on the surface of committed erythroid progenitors in the bone marrow resulting in their replication and maturation into functional erythrocytes. |
|
| Display_Name |
Epoetin Alfa |
|
| FULL_SYN |
epoetin alfa Epoetin Alfa Epoetin alfa Epoetin alfa-epbx EPO Epogen Eprex Procrit Retacrit |
|
| Has_Target | ||
| label |
Epoetin Alfa |
|
| Legacy Concept Name |
Epoetin_Alfa |
|
| NCI_Drug_Dictionary_ID |
41102 |
|
| PDQ_Closed_Trial_Search_ID |
41102 |
|
| PDQ_Open_Trial_Search_ID |
41102 |
|
| Preferred_Name |
Epoetin Alfa |
|
| prefixIRI |
Thesaurus:C2695 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0357126 |
|
| subClassOf |