National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Digitoxin

Synonyms

Crystodigin

(3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide

Crystalline Digitalin

CP4071

Cardidigin

DIGITOXIN

Digitoxin

Definitions

A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2634

Accepted_Therapeutic_Use_For

Atrial Fibrillation; Atrial Flutter; Congestive Heart Failure; Supraventricular Tachyarrhythmias.

ALT_DEFINITION

A substance that is being studied as a treatment for cancer.

CAS_Registry

71-63-6

CHEBI_ID

CHEBI:28544

Chemical_Formula

C41H64O13

code

C2634

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

FDA

GDC

DEFINITION

A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI)

FDA_UNII_Code

E90NZP2L9U

FULL_SYN

Crystodigin

(3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide

Crystalline Digitalin

CP4071

Cardidigin

DIGITOXIN

Digitoxin

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Digitoxin

Legacy Concept Name

Digitoxin

Maps_To

Digitoxin

NCI_Drug_Dictionary_ID

38332

NSC Number

7529

PDQ_Closed_Trial_Search_ID

38332

PDQ_Open_Trial_Search_ID

38332

Preferred_Name

Digitoxin

prefixIRI

Thesaurus:C2634

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0012258

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78322

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Delete Mapping To Ontology Source
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004074 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4017429 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.408.180.261.336 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0012258 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/MTHU005179 LOINC LOOM
http://stirdf.jst.go.jp/id/200907042815513309 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_28544 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_28544 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_28544 INBANCIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_28544 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_28544 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28544 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_28544 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_28544 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28544 NIFSTD LOOM
http://purl.obolibrary.org/obo/MESH_D004074 BERO LOOM
http://purl.obolibrary.org/obo/DRON_00016250 INBANCIDO LOOM
http://purl.obolibrary.org/obo/DRON_00016250 CIDO LOOM
http://purl.bioontology.org/ontology/LNC/LP16113-0 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/3403 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C2634 BERO LOOM
http://purl.bioontology.org/ontology/RCD/b12.. RCD LOOM
http://purl.bioontology.org/ontology/MESH/D004074 MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0005343 OMIT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000145817 INBANCIDO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000145817 CIDO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145817 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-80320 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3944 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.155.160.278 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018561 PMAPP-PMO LOOM
http://purl.jp/bio/4/id/200906060083086644 IOBC LOOM
http://purl.obolibrary.org/obo/dinto_DB01396 DINTO LOOM
https://go.drugbank.com/drugs/DB01396 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373534001 SNOMEDCT LOOM
http://www.co-ode.org/ontologies/galen#Digitoxin GALEN LOOM
http://bmi.utah.edu/ontologies/hfontology/C0012258 HFO LOOM
http://www.drugbank.ca/drugs/DB01396 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.155.580.130.500.336 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/C01AA04 ATC LOOM