National Cancer Institute Thesaurus

Last uploaded: June 25, 2019
Preferred Name

Valganciclovir

Synonyms

VALGANCICLOVIR

valganciclovir

Valganciclovir

L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl Ester

Definitions

A synthetic prodrug of ganciclovir, a nucleoside analogue of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, viral DNA synthesis, and viral replication. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2629

Accepted_Therapeutic_Use_For

Cytomegalovirus retinitis

ALT_DEFINITION

An antiviral agent that is being studied as a treatment for AIDS-related cytomegalovirus. It is changed in the body to ganciclovir.

CAS_Registry

175865-60-8

CHEBI_ID

CHEBI:63635

code

C2629

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic prodrug of ganciclovir, a nucleoside analogue of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, viral DNA synthesis, and viral replication. (NCI04)

Display_Name

Valganciclovir

FDA_UNII_Code

GCU97FKN3R

FULL_SYN

VALGANCICLOVIR

valganciclovir

Valganciclovir

L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl Ester

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66648

label

Valganciclovir

Legacy_Concept_Name

Valganciclovir

PDQ_Closed_Trial_Search_ID

38289

PDQ_Open_Trial_Search_ID

38289

Preferred_Name

Valganciclovir

prefixIRI

ncit:C2629

Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide

UMLS_CUI

C0909381

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29575

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1556

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C281

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http://purl.bioontology.org/ontology/NDDF/009135 NDDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000038289 PDQ LOOM
http://purl.bioontology.org/ontology/LNC/LP157730-5 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU047892 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D000077562 MESH LOOM
http://purl.obolibrary.org/obo/DRON_00019457 ODNAE LOOM
http://purl.obolibrary.org/obo/DRON_00019457 DRON LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/129476000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021263 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/275891 RXNORM LOOM
http://purl.bioontology.org/ontology/UATC/J05AB14 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C121677 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148704 NDFRT LOOM
http://purl.obolibrary.org/obo/CHEBI_63635 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63635 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63635 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_63635 CHEBI LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148704 ODAE LOOM