National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Palifermin

Synonyms

palifermin

Kepivance

Palifermin

rhKGF

PALIFERMIN

Keratinocyte Growth Factor, Recombinant Human

Growth Factor, Recombinant Human Keratinocyte

Recombinant Human Keratinocyte Growth Factor

rhu Keratinocyte Growth Factor

Definitions

A recombinant form of the endogenous human keratinocyte growth factor with cell growth promoting activity. Palifermin acts in the manner similar to the endogenous keratinocyte growth factor that binds to keratinocyte growth factor receptors on the epithelial cell surface in the lining of mouth and gastrointestinal tract. This results in stimulation of epithelial cell proliferation, differentiation and upregulation of cytoprotective mechanisms.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2455

Accepted_Therapeutic_Use_For

Severe oral mucositis with hematologic malignancies, chemotherapy- and radiotherapy-induced

ALT_DEFINITION

A form of keratinocyte growth factor (KGF) that is made in the laboratory. KGF stimulates the growth of cells that line the surface of the mouth and intestinal tract. Kepivance is used to prevent and treat oral mucositis (mouth sores) caused by high-dose chemotherapy and radiation therapy in leukemia and lymphoma. It is also being studied in the prevention and treatment of oral mucositis and dysphagia (difficulty swallowing) in other types of cancer. Kepivance is a type of recombinant human keratinocyte growth factor.

CAS_Registry

162394-19-6

code

C2455

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A recombinant form of the endogenous human keratinocyte growth factor with cell growth promoting activity. Palifermin acts in the manner similar to the endogenous keratinocyte growth factor that binds to keratinocyte growth factor receptors on the epithelial cell surface in the lining of mouth and gastrointestinal tract. This results in stimulation of epithelial cell proliferation, differentiation and upregulation of cytoprotective mechanisms.

Display_Name

Palifermin

FDA_UNII_Code

QMS40680K6

FULL_SYN

palifermin

Kepivance

Palifermin

rhKGF

PALIFERMIN

Keratinocyte Growth Factor, Recombinant Human

Growth Factor, Recombinant Human Keratinocyte

Recombinant Human Keratinocyte Growth Factor

rhu Keratinocyte Growth Factor

label

Palifermin

Legacy_Concept_Name

Recombinant_Human_Keratinocyte_Growth_Factor

PDQ_Closed_Trial_Search_ID

42905

PDQ_Open_Trial_Search_ID

42905

Preferred_Name

Palifermin

prefixIRI

ncit:C2455

Semantic_Type

Pharmacologic Substance

Amino Acid, Peptide, or Protein

UMLS_CUI

C0677829

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C496

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000023082 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00039 FTC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/417550009 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/dinto_DB00039 DINTO LOOM
http://purl.bioontology.org/ontology/RXNORM/196319 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4024900 VANDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042905 PDQ LOOM
http://purl.obolibrary.org/obo/DRON_00016188 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00016188 DRON LOOM
http://purl.bioontology.org/ontology/UATC/V03AF08 ATC LOOM