National Cancer Institute Thesaurus

Last uploaded: May 28, 2019
Preferred Name

Amphotericin B

Synonyms

AMPHOTERICIN B

Amphocil

AmB

amphotericin B

Amphotericin b

Amphotec

Amphotericin B

Definitions

A polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C238

ALT_DEFINITION

A drug used in the treatment of infections caused by fungi. It is a type of antifungal.

CAS_Registry

1397-89-3

CHEBI_ID

CHEBI:2682

Chemical_Formula

C47H73NO17

code

C238

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.

FDA_UNII_Code

7XU7A7DROE

FULL_SYN

AMPHOTERICIN B

Amphocil

AmB

amphotericin B

Amphotericin b

Amphotec

Amphotericin B

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62201

label

Amphotericin B

Legacy_Concept_Name

Amphotercin_B

NSC_Code

527017

Preferred_Name

Amphotericin B

prefixIRI

ncit:C238

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0002679

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C514

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://stirdf.jst.go.jp/id/200907033675065913 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/A07AA07 ATC LOOM
http://purl.bioontology.org/ontology/UATC/G01AA03 ATC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005038 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005038 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145996 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-52B20 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006779 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/77703004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/732 RXNORM LOOM
http://purl.jp/bio/4/id/200906088655935976 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000666 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.540.505.050 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP15581-9 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2682 FYPO LOOM
http://purl.bioontology.org/ontology/MESH/D000666 MESH LOOM
http://purl.bioontology.org/ontology/UATC/A01AB04 ATC LOOM
http://purl.bioontology.org/ontology/UATC/J02AA01 ATC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0002679 HFO LOOM
http://purl.bioontology.org/ontology/CSP/0191-9825 CRISP LOOM
http://purl.bioontology.org/ontology/NDDF/002887 NDDF LOOM
http://purl.bioontology.org/ontology/VANDF/4017616 VANDF LOOM
http://d-nb.info/gnd/4281236-7 FAST-TOPICAL LOOM