National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Cefotaxime Sodium

Synonyms

CEFOTAXIME SODIUM

Cefotaxime Sodium

Claforan

Definitions

The sodium salt form of cefotaxime, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Cefotaxime sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, cefotaxime sodium is more active against gram-negative bacteria and less active against gram-positive bacteria.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2328

CAS_Registry

64485-93-4

CHEBI_ID

CHEBI:3498

Chemical_Formula

C16H16N5O7S2.Na

code

C2328

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The sodium salt form of cefotaxime, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Cefotaxime sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, cefotaxime sodium is more active against gram-negative bacteria and less active against gram-positive bacteria.

FDA_UNII_Code

258J72S7TZ

FULL_SYN

CEFOTAXIME SODIUM

Cefotaxime Sodium

Claforan

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C354

label

Cefotaxime Sodium

Legacy Concept Name

Cefotaxime_Sodium

Preferred_Name

Cefotaxime Sodium

prefixIRI

Thesaurus:C2328

Semantic_Type

Organic Chemical

Pharmacologic Substance

Antibiotic

UMLS_CUI

C0700445

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

Delete Subject Author Type Created
No notes to display