loading...| Preferred Name |
Glucocorticoid |
|
| Synonyms |
Glucocorticoid glucocorticoid |
|
| Definitions |
A corticosteroid that supports a variety of cardiovascular, metabolic, immunologic, and homeostatic functions, and which binds specifically to the glucocorticoid receptor (GR; NR3C1). Glucocorticoid binding to GR leads to the transportation of the activated receptor-glucocorticoid complex to the nucleus, after which it binds to glucocorticoid response elements (GRE) and regulates the expression of GR-responsive genes. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2323 |
|
| ALT_DEFINITION |
A group of corticosteroids that affect carbohydrate metabolism, inhibit corticotropin secretion, and possess pronounced anti-inflammatory activity. A compound that belongs to the family of compounds called corticosteroids (steroids). Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive effects. They may be naturally produced (hormones) or synthetic (drugs). |
|
| CHEBI_ID |
CHEBI:24261 |
|
| code |
C2323 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118468 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259 |
|
| Contributing_Source |
CTRP NICHD |
|
| DEFINITION |
A corticosteroid that supports a variety of cardiovascular, metabolic, immunologic, and homeostatic functions, and which binds specifically to the glucocorticoid receptor (GR; NR3C1). Glucocorticoid binding to GR leads to the transportation of the activated receptor-glucocorticoid complex to the nucleus, after which it binds to glucocorticoid response elements (GRE) and regulates the expression of GR-responsive genes. |
|
| Display_Name |
Glucocorticoid |
|
| FULL_SYN |
Glucocorticoid glucocorticoid |
|
| label |
Glucocorticoid |
|
| Legacy Concept Name |
Glucocorticoid |
|
| Preferred_Name |
Glucocorticoid |
|
| prefixIRI |
Thesaurus:C2323 |
|
| Semantic_Type |
Organic Chemical Hormone |
|
| UMLS_CUI |
C0017710 |
|
| subClassOf |