National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Glucocorticoid

Synonyms

glucocorticoid

Glucocorticoid

Definitions

A corticosteroid that supports a variety of cardiovascular, metabolic, immunologic, and homeostatic functions, and which binds specifically to the glucocorticoid receptor (GR; NR3C1). Glucocorticoid binding to GR leads to the transportation of the activated receptor-glucocorticoid complex to the nucleus, after which it binds to glucocorticoid response elements (GRE) and regulates the expression of GR-responsive genes.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2323

ALT_DEFINITION

A group of corticosteroids that affect carbohydrate metabolism, inhibit corticotropin secretion, and possess pronounced anti-inflammatory activity.

A compound that belongs to the family of compounds called corticosteroids (steroids). Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive effects. They may be naturally produced (hormones) or synthetic (drugs).

CHEBI_ID

CHEBI:24261

code

C2323

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118468

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

Contributing_Source

NICHD

CTRP

DEFINITION

A corticosteroid that supports a variety of cardiovascular, metabolic, immunologic, and homeostatic functions, and which binds specifically to the glucocorticoid receptor (GR; NR3C1). Glucocorticoid binding to GR leads to the transportation of the activated receptor-glucocorticoid complex to the nucleus, after which it binds to glucocorticoid response elements (GRE) and regulates the expression of GR-responsive genes.

Display_Name

Glucocorticoid

FULL_SYN

glucocorticoid

Glucocorticoid

Has_NICHD_Parent

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Glucocorticoid

Legacy_Concept_Name

Glucocorticoid

NICHD_Hierarchy_Term

Glucocorticoid

Preferred_Name

Glucocorticoid

prefixIRI

ncit:C2323

Semantic_Type

Hormone

Organic Chemical

UMLS_CUI

C0017710

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2322

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http://purl.obolibrary.org/obo/IMR_0100036 TXPO LOOM
http://purl.obolibrary.org/obo/IMR_0100036 TXPO LOOM
http://purl.obolibrary.org/obo/IMR_0100036 TXPO LOOM
http://purl.obolibrary.org/obo/IMR_0100036 TXPO LOOM
http://purl.obolibrary.org/obo/IMR_0100036 TXPO LOOM
http://purl.obolibrary.org/obo/IMR_0100036 TXPO LOOM
http://purl.bioontology.org/ontology/CSP/0059-6844 CRISP LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/419933005 SNOMEDCT LOOM
http://www.projecthalo.com/aura#Glucocorticoid AURA LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005194 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004410 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004410 DMTO LOOM
http://purl.bioontology.org/ontology/RCD/X795h RCD LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 MCO LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 ZP LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_24261 OBA LOOM
http://purl.jp/bio/4/id/200906059025841485 IOBC LOOM
http://www.co-ode.org/ontologies/galen#Glucocorticoid GALEN LOOM
http://scai.fraunhofer.de/AlzheimerOntology#glucocorticoid ADO LOOM
http://www.gamuts.net/entity#glucocorticoid GAMUTS LOOM
http://www.semanticweb.org/ADMO#glucocorticoid ADMO LOOM