Preferred Name |
Bleomycin Antibiotic |
|
Synonyms |
Bleomycin Antibiotic Bleomycins |
|
Definitions |
A basic glycopeptide antineoplastic antibiotic isolated from Streptomyces verticillus. Bleomycin antibiotics form complexes with iron that react with molecular oxygen to produce superoxide and hydroxyl free radicals, causing single- and double-stranded breaks in DNA. These reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2311 |
|
CHEBI_ID |
CHEBI:22907 |
|
code |
C2311 |
|
DEFINITION |
A basic glycopeptide antineoplastic antibiotic isolated from Streptomyces verticillus. Bleomycin antibiotics form complexes with iron that react with molecular oxygen to produce superoxide and hydroxyl free radicals, causing single- and double-stranded breaks in DNA. These reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. |
|
FULL_SYN |
Bleomycin Antibiotic Bleomycins |
|
label |
Bleomycin Antibiotic |
|
Legacy Concept Name |
Bleomycin_Antibiotic |
|
NCI_META_CUI |
CL448369 |
|
Preferred_Name |
Bleomycin Antibiotic |
|
prefixIRI |
Thesaurus:C2311 |
|
Semantic_Type |
Chemical Viewed Functionally |
|
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.obolibrary.org/obo/NCIT_C2311 | BERO | LOOM |