loading...| Preferred Name |
Bleomycin Antibiotic |
|
| Synonyms |
Bleomycin Antibiotic Bleomycins |
|
| Definitions |
A basic glycopeptide antineoplastic antibiotic isolated from Streptomyces verticillus. Bleomycin antibiotics form complexes with iron that react with molecular oxygen to produce superoxide and hydroxyl free radicals, causing single- and double-stranded breaks in DNA. These reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2311 |
|
| CHEBI_ID |
CHEBI:22907 |
|
| code |
C2311 |
|
| DEFINITION |
A basic glycopeptide antineoplastic antibiotic isolated from Streptomyces verticillus. Bleomycin antibiotics form complexes with iron that react with molecular oxygen to produce superoxide and hydroxyl free radicals, causing single- and double-stranded breaks in DNA. These reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. |
|
| FULL_SYN |
Bleomycin Antibiotic Bleomycins |
|
| label |
Bleomycin Antibiotic |
|
| Legacy Concept Name |
Bleomycin_Antibiotic |
|
| NCI_META_CUI |
CL448369 |
|
| Preferred_Name |
Bleomycin Antibiotic |
|
| prefixIRI |
Thesaurus:C2311 |
|
| Semantic_Type |
Chemical Viewed Functionally |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/NCIT_C2311 | BERO | LOOM |