National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Prasterone

Synonyms

17-Hormoforin

Fidelin

PRASTERONE

Prasterone

Dehydroisoandrosterone

Diandron

GL701

Therapeutic Dehydroepiandrosterone

5,6-Dehydroisoandrosterone

dehydroepiandrosterone

Dehydroepiandrosterone

DHEA

3beta-Hydroxyandrost-5-en-17-one

Definitions

A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2265

Accepted_Therapeutic_Use_For

Adrenal insufficiency, replacement; Systemic lupus erythematosus, treatment and steroid treatment reduction

ALT_DEFINITION

A substance being studied in the prevention of cancer. It is a type of steroid.

CAS_Registry

53-43-0

CHEBI_ID

CHEBI:28689

Chemical_Formula

C19H28O2

code

C2265

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04)

Display_Name

Prasterone

FDA_UNII_Code

459AG36T1B

FULL_SYN

17-Hormoforin

Fidelin

PRASTERONE

Prasterone

Dehydroisoandrosterone

Diandron

GL701

Therapeutic Dehydroepiandrosterone

5,6-Dehydroisoandrosterone

dehydroepiandrosterone

Dehydroepiandrosterone

DHEA

3beta-Hydroxyandrost-5-en-17-one

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77220

label

Prasterone

Legacy_Concept_Name

Therapeutic_Dehydroepiandrosterone

NSC_Code

9896

PDQ_Closed_Trial_Search_ID

42419

PDQ_Open_Trial_Search_ID

42419

Preferred_Name

Prasterone

prefixIRI

ncit:C2265

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0011185

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C243

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000193467 NDFRT LOOM
http://purl.bioontology.org/ontology/UATC/G03XX01 ATC LOOM
http://purl.bioontology.org/ontology/UATC/A14AA07 ATC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042419 PDQ LOOM
http://purl.bioontology.org/ontology/RXNORM/3143 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4036745 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3664 OCHV LOOM