National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Prasterone

Synonyms

5,6-Dehydroisoandrosterone

Dehydroisoandrosterone

17-Hormoforin

Therapeutic Dehydroepiandrosterone

Dehydroepiandrosterone

dehydroepiandrosterone

3beta-Hydroxyandrost-5-en-17-one

DHEA

Diandron

Fidelin

GL701

PRASTERONE

Prasterone

Definitions

A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2265

Accepted_Therapeutic_Use_For

Adrenal insufficiency, replacement; Systemic lupus erythematosus, treatment and steroid treatment reduction

ALT_DEFINITION

A substance being studied in the prevention of cancer. It is a type of steroid.

CAS_Registry

53-43-0

CHEBI_ID

CHEBI:28689

Chemical_Formula

C19H28O2

code

C2265

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04)

Display_Name

Prasterone

FDA_UNII_Code

459AG36T1B

FULL_SYN

5,6-Dehydroisoandrosterone

Dehydroisoandrosterone

17-Hormoforin

Therapeutic Dehydroepiandrosterone

Dehydroepiandrosterone

dehydroepiandrosterone

3beta-Hydroxyandrost-5-en-17-one

DHEA

Diandron

Fidelin

GL701

PRASTERONE

Prasterone

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77220

label

Prasterone

Legacy Concept Name

Therapeutic_Dehydroepiandrosterone

NCI_Drug_Dictionary_ID

42419

NSC Number

9896

PDQ_Closed_Trial_Search_ID

42419

PDQ_Open_Trial_Search_ID

42419

Preferred_Name

Prasterone

prefixIRI

Thesaurus:C2265

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0011185

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C243

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