loading...| Preferred Name |
Interferon Beta-1B |
|
| Synonyms |
INTERFERON BETA-1B Interferon Beta-1B Recombinant interferon beta-1b Beta-ser-interferon Betaferon Betaseron |
|
| Definitions |
A recombinant and modified form of the endogenous cytokine human interferon (IFN) beta-1b, with antiproliferative, antiviral and immunomodulating activities. Upon administration, interferon beta-1b targets and binds to specific type I IFN receptors, which eventually results in the transcription and translation of genes containing an interferon-specific response element and leads to the production of various anti-viral proteins and modulates the production of various immune-modulating proteins. This reduces the production of certain pro-inflammatory cytokines while upregulating the anti-inflammatory cytokine interleukin 10 (IL-10), upregulates the expression of major histocompatibility (MHC) I proteins which allows for increased presentation of peptides derived from viral antigens, and activates CD8+ T cells as well as other immune cells. Endogenous IFN-beta-1b is produced following viral infection and it plays a key role in innate immune response against viral pathogens. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2221 |
|
| CAS_Registry |
145155-23-3 |
|
| code |
C2221 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 |
|
| Contributing_Source |
FDA |
|
| DEFINITION |
A recombinant and modified form of the endogenous cytokine human interferon (IFN) beta-1b, with antiproliferative, antiviral and immunomodulating activities. Upon administration, interferon beta-1b targets and binds to specific type I IFN receptors, which eventually results in the transcription and translation of genes containing an interferon-specific response element and leads to the production of various anti-viral proteins and modulates the production of various immune-modulating proteins. This reduces the production of certain pro-inflammatory cytokines while upregulating the anti-inflammatory cytokine interleukin 10 (IL-10), upregulates the expression of major histocompatibility (MHC) I proteins which allows for increased presentation of peptides derived from viral antigens, and activates CD8+ T cells as well as other immune cells. Endogenous IFN-beta-1b is produced following viral infection and it plays a key role in innate immune response against viral pathogens. |
|
| FDA_UNII_Code |
TTD90R31WZ |
|
| FULL_SYN |
INTERFERON BETA-1B Interferon Beta-1B Recombinant interferon beta-1b Beta-ser-interferon Betaferon Betaseron |
|
| label |
Interferon Beta-1B |
|
| Legacy Concept Name |
Interferon_Beta-1B |
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| NSC Number |
660166 |
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| Preferred_Name |
Interferon Beta-1B |
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| prefixIRI |
Thesaurus:C2221 |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C0244714 |
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| subClassOf |