loading...| Preferred Name |
Albuterol |
|
| Synonyms |
ALBUTEROL Albuterol |
|
| Definitions |
A racemic mixture of the r-isomer levalbuterol and s-albuterol, a short-acting sympathomimetic agent with bronchodilator activity. Albuterol stimulates beta-2 adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. Albuterol although to a lesser extent, also stimulates beta-1 adrenergic receptors, thereby increasing the force and rate of myocardial contraction. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C215 |
|
| CAS_Registry |
18559-94-9 |
|
| CHEBI_ID |
CHEBI:2549 |
|
| Chemical_Formula |
C13H21NO3 |
|
| code |
C215 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A racemic mixture of the r-isomer levalbuterol and s-albuterol, a short-acting sympathomimetic agent with bronchodilator activity. Albuterol stimulates beta-2 adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. Albuterol although to a lesser extent, also stimulates beta-1 adrenergic receptors, thereby increasing the force and rate of myocardial contraction. |
|
| Display_Name |
Albuterol |
|
| FDA_UNII_Code |
QF8SVZ843E |
|
| FULL_SYN |
ALBUTEROL Albuterol |
|
| Has_Salt_Form | ||
| label |
Albuterol |
|
| Legacy Concept Name |
Albuterol |
|
| NCI_Drug_Dictionary_ID |
81068 |
|
| Preferred_Name |
Albuterol |
|
| prefixIRI |
Thesaurus:C215 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0001927 |
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| subClassOf |