National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Lopinavir/Ritonavir

Synonyms

Lopinavir/Ritonavir

lopinavir/ritonavir

Kaletra

Definitions

A fixed combination of two protease inhibitors, lopinavir and ritonavir, used to treat human immunodeficiency virus (HIV) infection. The ritonavir in the combination drug increases the concentration and biological half-life of lopinavir but is not present in sufficient concentration to act as a protease inhibitor.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2096

ALT_DEFINITION

A combination of the drugs ritonavir and lopinavir. It is used to treat infection with HIV (the virus that causes AIDS). It is also being studied in the treatment of some types of cancer. Lopinavir/ritonavir blocks the ability of HIV to make copies of itself and may help other anticancer drugs work better or may block the growth of cancer cells. Ritonavir blocks the breakdown of lopinavir. Lopinavir/ritonavir is a type of anti-HIV agent and a type of protease inhibitor.

code

C2096

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

Contributing_Source

CTRP

DEFINITION

A fixed combination of two protease inhibitors, lopinavir and ritonavir, used to treat human immunodeficiency virus (HIV) infection. The ritonavir in the combination drug increases the concentration and biological half-life of lopinavir but is not present in sufficient concentration to act as a protease inhibitor.

Display_Name

Lopinavir/Ritonavir

FULL_SYN

Lopinavir/Ritonavir

lopinavir/ritonavir

Kaletra

label

Lopinavir/Ritonavir

Legacy Concept Name

Lopinavir_Ritonavir

Preferred_Name

Lopinavir/Ritonavir

prefixIRI

Thesaurus:C2096

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0939237

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97366

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