loading...| Preferred Name |
Mesna |
|
| Synonyms |
Mercaptoethane Sulfonate Sodium 2-Mercaptoethane Sulfonate Sodium 2-Mercaptoethanesulphonate 2-Mercaptoethanesulfonate, Sodium Salt Mercaptoethanesulfonate Mistabronco 2-Mercaptoethanesulfonic Acid Sodium Salt Ausobronc D-7093 Filesna MESNA Mesna Mesnex Mesnil Mesnum Mexan Mistabron Mitexan Mucofluid Mucolene UCB 3983 Uromitexan Ziken mesna |
|
| Definitions |
A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192 |
|
| Accepted_Therapeutic_Use_For |
Ifosfamide-induced hemorrhagic cystitis, prophylaxis |
|
| ALT_DEFINITION |
A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide. |
|
| CAS_Registry |
19767-45-4 |
|
| Chemical_Formula |
C2H5O3S2.Na |
|
| code |
C192 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04) |
|
| Display_Name |
Mesna |
|
| FDA_UNII_Code |
NR7O1405Q9 |
|
| FULL_SYN |
Mercaptoethane Sulfonate Sodium 2-Mercaptoethane Sulfonate Sodium 2-Mercaptoethanesulphonate 2-Mercaptoethanesulfonate, Sodium Salt Mercaptoethanesulfonate Mistabronco 2-Mercaptoethanesulfonic Acid Sodium Salt Ausobronc D-7093 Filesna MESNA Mesna Mesnex Mesnil Mesnum Mexan Mistabron Mitexan Mucofluid Mucolene UCB 3983 Uromitexan Ziken mesna |
|
| Is_Value_For_GDC_Property | ||
| label |
Mesna |
|
| Legacy Concept Name |
Mesna |
|
| Maps_To |
Mesna |
|
| NCI_Drug_Dictionary_ID |
39759 |
|
| NSC Number |
113891 |
|
| PDQ_Closed_Trial_Search_ID |
39759 |
|
| PDQ_Open_Trial_Search_ID |
39759 |
|
| Preferred_Name |
Mesna |
|
| prefixIRI |
Thesaurus:C192 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0000294 |
|
| subClassOf |