loading...| Preferred Name |
Valdecoxib |
|
| Synonyms |
4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide Bextra SC 65872 VALDECOXIB Valdecoxib valdecoxib |
|
| Definitions |
A sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1869 |
|
| Accepted_Therapeutic_Use_For |
Osteoarthritis; rheumatoid arthritis; dysmenorrhea |
|
| ALT_DEFINITION |
A substance that is being studied as a treatment for pain and other side effects of cancer therapy. It belongs to the family of drugs called COX-2 inhibitors. |
|
| CAS_Registry |
181695-72-7 |
|
| CHEBI_ID |
CHEBI:63634 |
|
| Chemical_Formula |
C16H14N2O3S |
|
| code |
C1869 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation. |
|
| FDA_UNII_Code |
2919279Q3W |
|
| FULL_SYN |
4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide Bextra SC 65872 VALDECOXIB Valdecoxib valdecoxib |
|
| label |
Valdecoxib |
|
| Legacy Concept Name |
Valdecoxib |
|
| NCI_Drug_Dictionary_ID |
38320 |
|
| PDQ_Closed_Trial_Search_ID |
38320 |
|
| PDQ_Open_Trial_Search_ID |
38320 |
|
| Preferred_Name |
Valdecoxib |
|
| prefixIRI |
Thesaurus:C1869 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0913246 |
|
| subClassOf |