loading...| Preferred Name |
Micafungin |
|
| Synonyms |
FK463 MICAFUNGIN Micafungin |
|
| Definitions |
A semi-synthetic echinocandin derived from a natural product of the fungus Coleophama empedri with potent antifungal activity. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3-beta-D-glucan synthase, an enzyme essential for fungal cell wall synthesis. Inhibition of this enzyme weakens of the cell wall, thereby leading to osmotic lysis and eventually, fungal cell death. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1850 |
|
| ALT_DEFINITION |
An antibiotic/antifungal drug used to treat infection. |
|
| CAS_Registry |
235114-32-6 |
|
| CHEBI_ID |
CHEBI:600520 |
|
| Chemical_Formula |
C56H71N9O23S |
|
| code |
C1850 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A semi-synthetic echinocandin derived from a natural product of the fungus Coleophama empedri with potent antifungal activity. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3-beta-D-glucan synthase, an enzyme essential for fungal cell wall synthesis. Inhibition of this enzyme weakens of the cell wall, thereby leading to osmotic lysis and eventually, fungal cell death. |
|
| Display_Name |
Micafungin |
|
| FDA_UNII_Code |
R10H71BSWG |
|
| FULL_SYN |
FK463 MICAFUNGIN Micafungin |
|
| Has_Salt_Form | ||
| label |
Micafungin |
|
| Legacy Concept Name |
Micafungin |
|
| NCI_Drug_Dictionary_ID |
43552 |
|
| PDQ_Closed_Trial_Search_ID |
43552 |
|
| PDQ_Open_Trial_Search_ID |
43552 |
|
| Preferred_Name |
Micafungin |
|
| prefixIRI |
Thesaurus:C1850 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C1120386 |
|
| subClassOf |