National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Rofecoxib

Synonyms

Vioxx

ROFECOXIB

Rofecoxib

rofecoxib

4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone

MK 966

Definitions

A synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1832

Accepted_Therapeutic_Use_For

Pain; dysmenorrhea; osteoarthritis; rheumatoid arthritis

ALT_DEFINITION

A drug that was being used for pain relief and was being studied for its ability to prevent cancer and to prevent the growth of new blood vessels that tumors need to grow. It is a type of nonsteroidal anti-inflammatory drug and a type of antiangiogenesis agent. Rofecoxib was taken off the market in the U.S. because of safety concerns.

CAS_Registry

162011-90-7

CHEBI_ID

CHEBI:8887

Chemical_Formula

C17H14O4S

code

C1832

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

Contributing_Source

FDA

DEFINITION

A synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. (NCI04)

FDA_UNII_Code

0QTW8Z7MCR

FULL_SYN

Vioxx

ROFECOXIB

Rofecoxib

rofecoxib

4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone

MK 966

label

Rofecoxib

Legacy_Concept_Name

Rofecoxib

NSC_Code

720256

PDQ_Closed_Trial_Search_ID

38568

PDQ_Open_Trial_Search_ID

38568

Preferred_Name

Rofecoxib

prefixIRI

ncit:C1832

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0762662

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80509

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http://purl.bioontology.org/ontology/NDFRT/N0000148611 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP171636-6 LOINC LOOM
http://purl.obolibrary.org/obo/DRON_00015719 ODNAE LOOM
http://purl.obolibrary.org/obo/DRON_00015719 DRON LOOM
http://scai.fraunhofer.de/AlzheimerOntology#rofecoxib ADO LOOM
http://purl.bioontology.org/ontology/UATC/M01AH02 ATC LOOM
http://doe-generated-ontology.com/OntoAD#C0762662 ONTOAD LOOM
http://purl.bioontology.org/ontology/RXNORM/232158 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C116926 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/116095002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021160 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8887 NIFSTD LOOM
http://purl.bioontology.org/ontology/MESH/C116926 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/007787 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387008005 SNOMEDCT LOOM
http://www.co-ode.org/ontologies/galen#Rofecoxib GALEN LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000038568 PDQ LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148611 ODAE LOOM
http://www.drugbank.ca/drugs/DB00533 FTC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0762662 HFO LOOM