loading...| Preferred Name |
Ursodiol |
|
| Synonyms |
Ursodeoxycholic acid Ursodeoxycholic Acid (3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid Actigall Deursil UDCA URSO URSODIOL Ursodiol ursodiol |
|
| Definitions |
A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1818 |
|
| Accepted_Therapeutic_Use_For |
Gallstone disolution; Primary biliary cirrhosis |
|
| ALT_DEFINITION |
A drug that is used to dissolve gallstones in people who can't have surgery to remove them. It is also being studied in the prevention of colorectal cancer. Ursodiol belongs to the family of drugs called anticholelithics. |
|
| CAS_Registry |
128-13-2 |
|
| CHEBI_ID |
CHEBI:9907 |
|
| Chemical_Formula |
C24H40O4 |
|
| code |
C1818 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract. |
|
| Display_Name |
Ursodiol |
|
| FDA_UNII_Code |
724L30Y2QR |
|
| FULL_SYN |
Ursodeoxycholic acid Ursodeoxycholic Acid (3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid Actigall Deursil UDCA URSO URSODIOL Ursodiol ursodiol |
|
| label |
Ursodiol |
|
| Legacy Concept Name |
Ursodiol |
|
| NCI_Drug_Dictionary_ID |
306453 |
|
| NSC Number |
657950 683769 |
|
| PDQ_Closed_Trial_Search_ID |
306453 |
|
| PDQ_Open_Trial_Search_ID |
306453 |
|
| Preferred_Name |
Ursodiol |
|
| prefixIRI |
Thesaurus:C1818 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0042105 |
|
| subClassOf |