loading...| Preferred Name |
Raloxifene Hydrochloride |
|
| Synonyms |
RALOXIFENE HYDROCHLORIDE Raloxifene HCl Keoxifene Hydrochloride Raloxifene hydrochloride (6-Hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone Hydrochloride raloxifene hydrochloride Raloxifene.HCl Raloxifene Hydrochloride Evista LY-156758 Optruma |
|
| Definitions |
The hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor modulator (SERM) with lipid lowering effects and activity against osteoporosis. Raloxifene hydrochloride specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it promotes or suppresses the transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In tissue like bone, it decreases bone resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts an anti-proliferative effect on estrogen-sensitive breast cancer. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1762 |
|
| Accepted_Therapeutic_Use_For |
Breast cancer prevention |
|
| ALT_DEFINITION |
A drug used to reduce the risk of invasive breast cancer in postmenopausal women who are at high risk of the disease or who have osteoporosis. It is also used to prevent and treat osteoporosis in postmenopausal women. It is also being studied in the prevention of breast cancer in certain premenopausal women and in the prevention and treatment of other conditions. Evista blocks the effects of the hormone estrogen in the breast and increases the amount of calcium in bone. It is a type of selective estrogen receptor modulator (SERM). |
|
| CAS_Registry |
82640-04-8 |
|
| CHEBI_ID |
CHEBI:50740 |
|
| Chemical_Formula |
C28H27NO4S.HCl |
|
| code |
C1762 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor modulator (SERM) with lipid lowering effects and activity against osteoporosis. Raloxifene hydrochloride specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it promotes or suppresses the transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In tissue like bone, it decreases bone resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts an anti-proliferative effect on estrogen-sensitive breast cancer. |
|
| Display_Name |
Raloxifene Hydrochloride |
|
| FDA_UNII_Code |
4F86W47BR6 |
|
| FULL_SYN |
RALOXIFENE HYDROCHLORIDE Raloxifene HCl Keoxifene Hydrochloride Raloxifene hydrochloride (6-Hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone Hydrochloride raloxifene hydrochloride Raloxifene.HCl Raloxifene Hydrochloride Evista LY-156758 Optruma |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Raloxifene Hydrochloride |
|
| Legacy Concept Name |
Raloxifene_Hydrochloride |
|
| Maps_To |
Raloxifene Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
43109 |
|
| NSC Number |
706725 |
|
| PDQ_Closed_Trial_Search_ID |
43109 |
|
| PDQ_Open_Trial_Search_ID |
43109 |
|
| Preferred_Name |
Raloxifene Hydrochloride |
|
| prefixIRI |
Thesaurus:C1762 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0618111 |
|
| subClassOf |