National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Serpin

Synonyms

Serpin

Definitions

Irreversible serine proteinase inhibitors that exert their action on peptidases. Serpins can be localized inside, or outside of the cell, and are found in all groups of organisms with the exception of fungi. In human plasma, serpins represent approximately 2% of the total protein present.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17124

code

C17124

DEFINITION

Irreversible serine proteinase inhibitors that exert their action on peptidases. Serpins can be localized inside, or outside of the cell, and are found in all groups of organisms with the exception of fungi. In human plasma, serpins represent approximately 2% of the total protein present.

DesignNote

Some members of the serpin family do not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins. These family members exhibit no serine protease inhibitory activity. (UniProt)

FULL_SYN

Serpin

label

Serpin

Legacy Concept Name

Serpin

NCI_META_CUI

CL554612

Preferred_Name

Serpin

prefixIRI

Thesaurus:C17124

Semantic_Type

Amino Acid, Peptide, or Protein

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20130

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