loading...| Preferred Name |
Epidermal Growth Factor Receptor |
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| Synonyms |
Epidermal Growth Factor Receptor Protein-Tyrosine Kinase epidermal growth factor receptor Receptor Tyrosine-Protein Kinase erbB-1 Cell Proliferation-Inducing Protein 61 Cell Growth Inhibiting Protein 40 ERBB Protein EGF Receptor EC 2.7.10.1 Urogastrone Receptor Erb-B2 Receptor Tyrosine Kinase 1 Proto-Oncogene c-erbB-1 Epidermal Growth Factor Receptor EGFR ErbB1 HER-1 HER1 c-erbB-1 erbB-1 |
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| Definitions |
Epidermal growth factor receptor (1210 aa, ~134 kDa) is encoded by the human EGFR gene. This protein plays a role in cell-cell adhesion, cell migration, cell proliferation and signal transduction. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17068 |
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| ALT_DEFINITION |
The protein found on the surface of some cells and to which epidermal growth factor binds, causing the cells to divide. It is found at abnormally high levels on the surface of many types of cancer cells, so these cells may divide excessively in the presence of epidermal growth factor. |
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| code |
C17068 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
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| Contributing_Source |
CTRP |
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| DEFINITION |
Epidermal growth factor receptor (1210 aa, ~134 kDa) is encoded by the human EGFR gene. This protein plays a role in cell-cell adhesion, cell migration, cell proliferation and signal transduction. |
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| DesignNote |
The Epidermal Growth Factor Receptor is a protein tyrosine kinase with two glycoprotein components of different molecular weight; both contain phosphotyrosine and phosphothreonine but only the higher molecular weight form contains phosphoserine. The tyrosine kinase activity is required for internalization or degradation of EGF-EGFR receptor complexes. EGF stimulation of the receptor initiates DNA and protein synthesis in target cells. The receptor is not found on mitotically quiescent cells except the stomach where it controls synthesis and release of digestive enzymes and gastric acid. TGF alpha also binds to and activates the receptor. |
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| Display_Name |
Epidermal Growth Factor Receptor |
|
| FULL_SYN |
Epidermal Growth Factor Receptor Protein-Tyrosine Kinase epidermal growth factor receptor Receptor Tyrosine-Protein Kinase erbB-1 Cell Proliferation-Inducing Protein 61 Cell Growth Inhibiting Protein 40 ERBB Protein EGF Receptor EC 2.7.10.1 Urogastrone Receptor Erb-B2 Receptor Tyrosine Kinase 1 Proto-Oncogene c-erbB-1 Epidermal Growth Factor Receptor EGFR ErbB1 HER-1 HER1 c-erbB-1 erbB-1 |
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| label |
Epidermal Growth Factor Receptor |
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| Legacy Concept Name |
Epidermal_Growth_Factor_Receptor |
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| OMIM_Number |
131550 |
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| Preferred_Name |
Epidermal Growth Factor Receptor |
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| prefixIRI |
Thesaurus:C17068 |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme Receptor |
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| Swiss_Prot |
P00533 |
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| UMLS_CUI |
C1739039 |
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| subClassOf |