National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Warfarin Sodium

Synonyms

Waran

Warfarin Sodium

Prothromadin

Marevan

Panwarfin

WARFARIN SODIUM

Tintorane

Coumadin

Warfilone

Definitions

The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1658

CAS_Registry

129-06-6

CHEBI_ID

CHEBI:10034

Chemical_Formula

C19H15O4.Na

code

C1658

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented.

Display_Name

Warfarin Sodium

FDA_UNII_Code

6153CWM0CL

FULL_SYN

Waran

Warfarin Sodium

Prothromadin

Marevan

Panwarfin

WARFARIN SODIUM

Tintorane

Coumadin

Warfilone

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C945

label

Warfarin Sodium

Legacy_Concept_Name

Warfarin_Sodium

Preferred_Name

Warfarin Sodium

prefixIRI

ncit:C1658

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0376218

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C263

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45597

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