loading...| Preferred Name |
Warfarin Sodium |
|
| Synonyms |
Prothromadin WARFARIN SODIUM Warfarin Sodium Coumadin Marevan Panwarfin Tintorane Waran Warfilone |
|
| Definitions |
The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1658 |
|
| CAS_Registry |
129-06-6 |
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| CHEBI_ID |
CHEBI:10034 |
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| Chemical_Formula |
C19H15O4.Na |
|
| code |
C1658 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented. |
|
| Display_Name |
Warfarin Sodium |
|
| FDA_UNII_Code |
6153CWM0CL |
|
| FULL_SYN |
Prothromadin WARFARIN SODIUM Warfarin Sodium Coumadin Marevan Panwarfin Tintorane Waran Warfilone |
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| Has_Free_Acid_Or_Base_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Warfarin Sodium |
|
| Legacy Concept Name |
Warfarin_Sodium |
|
| Maps_To |
Warfarin Sodium |
|
| NCI_Drug_Dictionary_ID |
39740 |
|
| PDQ_Closed_Trial_Search_ID |
39740 |
|
| PDQ_Open_Trial_Search_ID |
39740 |
|
| Preferred_Name |
Warfarin Sodium |
|
| prefixIRI |
Thesaurus:C1658 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0376218 |
|
| subClassOf |