National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Anastrozole

Synonyms

ICI-D1033

anastrozole

Anastrazole

Alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile

Anastrozole

ICI D1033

2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile)

Arimidex

ANASTROZOLE

ZD-1033

Definitions

A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1607

Accepted_Therapeutic_Use_For

Hormone Receptor-Positive Early Breast cancer

ALT_DEFINITION

An anticancer drug that is used to decrease estrogen production and suppress the growth of tumors that need estrogen to grow. It is a type of nonsteroidal aromatase inhibitor.

CAS_Registry

120511-73-1

CHEBI_ID

CHEBI:2704

Chemical_Formula

C17H19N5

code

C1607

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04)

Display_Name

Anastrozole

FDA_UNII_Code

2Z07MYW1AZ

FULL_SYN

ICI-D1033

anastrozole

Anastrazole

Alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile

Anastrozole

ICI D1033

2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile)

Arimidex

ANASTROZOLE

ZD-1033

label

Anastrozole

Legacy_Concept_Name

Anastrozole

NSC_Code

719344

PDQ_Closed_Trial_Search_ID

42540

PDQ_Open_Trial_Search_ID

42540

Preferred_Name

Anastrozole

prefixIRI

ncit:C1607

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0290883

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2018

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http://purl.bioontology.org/ontology/PDQ/CDR0000042540 PDQ LOOM
http://purl.bioontology.org/ontology/RXNORM/84857 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/84857 NLMVS LOOM
http://purl.jp/bio/4/id/200906019270193900 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386910003 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 DRON LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148427 ODAE LOOM
http://purl.bioontology.org/ontology/MESH/C090450 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C090450 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Anastrozole GALEN LOOM
http://purl.bioontology.org/ontology/UATC/L02BG03 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108774000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148427 NDFRT LOOM
http://www.drugbank.ca/drugs/DB01217 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4020948 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/005094 NDDF LOOM
http://purl.bioontology.org/ontology/RCD/heC.. RCD LOOM