loading...| Preferred Name |
Anastrozole |
|
| Synonyms |
Alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile ANASTROZOLE 2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile) Anastrozole Anastrazole anastrozole Arimidex ICI D1033 ICI-D1033 ZD-1033 |
|
| Definitions |
A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1607 |
|
| Accepted_Therapeutic_Use_For |
Hormone Receptor-Positive Early Breast cancer |
|
| ALT_DEFINITION |
An anticancer drug that is used to decrease estrogen production and suppress the growth of tumors that need estrogen to grow. It is a type of nonsteroidal aromatase inhibitor. |
|
| CAS_Registry |
120511-73-1 |
|
| CHEBI_ID |
CHEBI:2704 |
|
| Chemical_Formula |
C17H19N5 |
|
| code |
C1607 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04) |
|
| Display_Name |
Anastrozole |
|
| FDA_UNII_Code |
2Z07MYW1AZ |
|
| FULL_SYN |
Alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile ANASTROZOLE 2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile) Anastrozole Anastrazole anastrozole Arimidex ICI D1033 ICI-D1033 ZD-1033 |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Anastrozole |
|
| Legacy Concept Name |
Anastrozole |
|
| Maps_To |
Anastrozole |
|
| NCI_Drug_Dictionary_ID |
42540 |
|
| NSC Number |
719344 |
|
| PDQ_Closed_Trial_Search_ID |
42540 |
|
| PDQ_Open_Trial_Search_ID |
42540 |
|
| Preferred_Name |
Anastrozole |
|
| prefixIRI |
Thesaurus:C1607 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0290883 |
|
| subClassOf |