National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Antineoplastic Alkylating Agent

Synonyms

Antineoplastic Alkylating Agent

Chemotherapy Alkylating Agents

Chemotherapy Alkylators

Definitions

An antineoplastic agent that replaces hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1590

code

C1590

DEFINITION

An antineoplastic agent that replaces hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth.

FULL_SYN

Antineoplastic Alkylating Agent

Chemotherapy Alkylating Agents

Chemotherapy Alkylators

label

Antineoplastic Alkylating Agent

Legacy Concept Name

Antineoplastic_Alkylating_Agent

Preferred_Name

Antineoplastic Alkylating Agent

prefixIRI

Thesaurus:C1590

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C0282532

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2842

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http://purl.obolibrary.org/obo/NCIT_C1590 BERO LOOM