National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Antineoplastic Alkylating Agent

Synonyms

Chemotherapy Alkylating Agents

Chemotherapy Alkylators

Antineoplastic Alkylating Agent

Definitions

An antineoplastic agent that replaces hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1590

code

C1590

DEFINITION

An antineoplastic agent that replaces hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth.

FULL_SYN

Chemotherapy Alkylating Agents

Chemotherapy Alkylators

Antineoplastic Alkylating Agent

label

Antineoplastic Alkylating Agent

Legacy_Concept_Name

Antineoplastic_Alkylating_Agent

Preferred_Name

Antineoplastic Alkylating Agent

prefixIRI

ncit:C1590

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C0282532

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C274

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