National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Levofloxacin

Synonyms

Levofloxacin

Levaquin

LEVOFLOXACIN

Quixin

levofloxacin

Definitions

A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1586

ALT_DEFINITION

A substance used to treat bacterial infections. It belongs to the family of drugs called quinolone antibiotics.

CAS_Registry

138199-71-0

Chemical_Formula

2C18H20FN3O4.H2O

code

C1586

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.

Display_Name

Levofloxacin

FDA_UNII_Code

6GNT3Y5LMF

FULL_SYN

Levofloxacin

Levaquin

LEVOFLOXACIN

Quixin

levofloxacin

label

Levofloxacin

Legacy_Concept_Name

Levofloxacin

PDQ_Closed_Trial_Search_ID

37941

PDQ_Open_Trial_Search_ID

37941

Preferred_Name

Levofloxacin

prefixIRI

ncit:C1586

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0282386

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C795

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http://purl.bioontology.org/ontology/MESH/D064704 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4021005 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148474 NDFRT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148474 ODAE LOOM
http://purl.bioontology.org/ontology/UATC/J01MA12 ATC LOOM
http://www.drugbank.ca/drugs/DB01137 FTC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU009097 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/LP17276-4 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387552007 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906067864073585 IOBC LOOM
http://purl.jp/bio/4/id/200906067864073585 IOBC LOOM
http://purl.jp/bio/4/id/200906067864073585 IOBC LOOM
http://purl.jp/bio/4/id/200906067864073585 IOBC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000037941 PDQ LOOM
http://purl.bioontology.org/ontology/RXNORM/82122 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907015113123220 IOBC LOOM
http://stirdf.jst.go.jp/id/200907015113123220 IOBC LOOM
http://stirdf.jst.go.jp/id/200907015113123220 IOBC LOOM
http://stirdf.jst.go.jp/id/200907015113123220 IOBC LOOM
http://purl.obolibrary.org/obo/ARO_0000071 ARO LOOM
http://purl.obolibrary.org/obo/ARO_0000071 ARO LOOM
http://purl.bioontology.org/ontology/NDDF/006299 NDDF LOOM
http://www.co-ode.org/ontologies/galen#Levofloxacin GALEN LOOM
http://purl.bioontology.org/ontology/SNMI/C-55791 SNMI LOOM
http://purl.bioontology.org/ontology/RCD/egC.. RCD LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005582 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005582 DMTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.810.835.322.500.500 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D064704 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_63598 CHEBI LOOM
http://purl.bioontology.org/ontology/UATC/S01AE05 ATC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005578 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005578 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005578 DMTO LOOM