National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Alitretinoin

Synonyms

9-cis Retinoic Acid

9-cis-Retinoic Acid

9-cis retinoic acid

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid

9-Cis-Retinoic Acid

ALITRETINOIN

Retinoicacid-9-cis

Alitretinoin

9-cRA

9-cis-RA

ALRT1057

LGD1057

Panretin

Panretyn

Panrexin

Definitions

An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1574

Accepted_Therapeutic_Use_For

Topical treatment of cutaneous lesions in patients with AIDS-related Kaposi sarcoma

ALT_DEFINITION

A drug being studied for cancer prevention. It belongs to the family of drugs called retinoids.

CAS_Registry

5300-03-8

CHEBI_ID

CHEBI:50648

Chemical_Formula

C20H28O2

code

C1574

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

FDA

GDC

HemOnc

DEFINITION

An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells.

FDA_UNII_Code

1UA8E65KDZ

FULL_SYN

9-cis Retinoic Acid

9-cis-Retinoic Acid

9-cis retinoic acid

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid

9-Cis-Retinoic Acid

ALITRETINOIN

Retinoicacid-9-cis

Alitretinoin

9-cRA

9-cis-RA

ALRT1057

LGD1057

Panretin

Panretyn

Panrexin

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Alitretinoin

Legacy Concept Name

Alitretinoin

Maps_To

Alitretinoin

NCI_Drug_Dictionary_ID

42147

NSC Number

659772

PDQ_Closed_Trial_Search_ID

42147

PDQ_Open_Trial_Search_ID

42147

Preferred_Name

Alitretinoin

prefixIRI

Thesaurus:C1574

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0281666

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C804

Delete Subject Author Type Created
No notes to display