National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Letrozole

Synonyms

4,4'-(1H-1,2,4triazol-1-ylmethylene)dibenzonitrile

CGS 20267

Femara

Fempro

LETROZOLE

Letrozole

letrozole

Definitions

A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1527

Accepted_Therapeutic_Use_For

Hormone receptor-positive early breast cancer; Delayed puberty; Endometrial cancer; Ovulatory induction

ALT_DEFINITION

A drug used to treat advanced breast cancer in postmenopausal women. Letrozole causes a decrease in the amount of estrogen made by the body. It is a type of aromatase inhibitor.

CAS_Registry

112809-51-5

CHEBI_ID

CHEBI:6413

Chemical_Formula

C17H11N5

code

C1527

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

DEFINITION

A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.

Display_Name

Letrozole

FDA_UNII_Code

7LKK855W8I

FULL_SYN

4,4'-(1H-1,2,4triazol-1-ylmethylene)dibenzonitrile

CGS 20267

Femara

Fempro

LETROZOLE

Letrozole

letrozole

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16307

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Letrozole

Legacy Concept Name

Letrozole

Maps_To

Letrozole

NCI_Drug_Dictionary_ID

42086

NSC Number

719345

PDQ_Closed_Trial_Search_ID

42086

PDQ_Open_Trial_Search_ID

42086

Preferred_Name

Letrozole

prefixIRI

Thesaurus:C1527

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0246421

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2018

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D000077289 MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026175 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042086 PDQ LOOM
http://www.drugbank.ca/drugs/DB01006 FTC LOOM
http://purl.obolibrary.org/obo/NCIT_C1527 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/006298 NDDF LOOM
https://go.drugbank.com/drugs/DB01006 MDM LOOM
http://purl.jp/bio/4/id/200906050381941110 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C067431 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Letrozole GALEN LOOM
http://purl.bioontology.org/ontology/RCD/heE.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148513 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/L02BG04 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#25142 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0246421 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 NIFSTD LOOM
http://stirdf.jst.go.jp/id/200907081310334197 IOBC LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass731d61fb_cd1b_4ae6_b7cc_326a9444e994 WWECA LOOM
http://purl.bioontology.org/ontology/RXNORM/72965 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/72965 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386911004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021049 VANDF LOOM