National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Docetaxel

Synonyms

DOCETAXEL

Docetaxel

Docecad

[2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester

RP56976

N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol

docetaxel

Taxotere Injection Concentrate

Taxotere

Definitions

A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526

Accepted_Therapeutic_Use_For

Breast cancer; Esophageal cancer; Gastric cancer; Head/Neck cancers; Locally Advanced or Metastatic Non small-cell lung cancer; Ovarian cancer; Metastatic Prostate cancer

ALT_DEFINITION

A drug used together with other drugs to treat certain types of breast cancer, stomach cancer, prostate cancer, and certain types of head and neck cancer. It is also being studied in the treatment of other types of cancer. Docetaxel is a type of mitotic inhibitor.

CAS_Registry

148408-66-6

CHEBI_ID

CHEBI:59809

Chemical_Formula

C43H53NO14.3H2O

code

C1526

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)

Display_Name

Docetaxel

FDA_UNII_Code

15H5577CQD

FULL_SYN

DOCETAXEL

Docetaxel

Docecad

[2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester

RP56976

N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol

docetaxel

Taxotere Injection Concentrate

Taxotere

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18115

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20450

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17219

label

Docetaxel

Legacy_Concept_Name

Docetaxel

NSC_Code

628503

PDQ_Closed_Trial_Search_ID

41657

PDQ_Open_Trial_Search_ID

41657

Preferred_Name

Docetaxel

prefixIRI

ncit:C1526

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0246415

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67437

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1490

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#C067311 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4020968 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/72962 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0246415 OCHV LOOM
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Docetaxel PCAO LOOM
http://purl.bioontology.org/ontology/MESH/D000077143 MESH LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148441 ODAE LOOM
http://www.co-ode.org/ontologies/galen#Docetaxel GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386918005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041657 PDQ LOOM
http://purl.bioontology.org/ontology/RCD/h5E.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148441 NDFRT LOOM
http://www.ifomis.org/acgt/1.0#Docetaxel ACGT-MO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#25141 OCHV LOOM
http://d-nb.info/gnd/4501869-8 FAST-TOPICAL LOOM
http://www.drugbank.ca/drugs/DB01248 FTC LOOM
http://purl.jp/bio/4/id/200906091109109292 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/L01CD02 ATC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 ROO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 ROO SAME_URI
http://stirdf.jst.go.jp/id/200907094393798330 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/005187 NDDF LOOM