National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Raloxifene

Synonyms

RALOXIFENE

LY 139481

raloxifene

Keoxifene

[6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

Raloxifene

Definitions

A selective benzothiophene estrogen receptor modulator (SERM). Raloxifene binds to estrogen receptors (ER) as a mixed estrogen agonist/antagonist; it displays both an ER-alpha-selective partial agonist/antagonist effect and a pure ER-beta-selective antagonist effect. This agent functions as an estrogen agonist in some tissues (bones, lipid metabolism) and as an estrogen antagonist in others (endometrium and breasts), with the potential for producing some of estrogen's beneficial effects without producing its adverse effects. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1518

Accepted_Therapeutic_Use_For

Breast cancer; Cardiovascular Disease prophylaxis; Osteoporosis

ALT_DEFINITION

The active ingredient in a drug used to reduce the risk of invasive breast cancer in postmenopausal women who are at high risk of the disease or who have osteoporosis. It is also used to prevent and treat osteoporosis in postmenopausal women. It is also being studied in the prevention of breast cancer in certain premenopausal women and in the prevention and treatment of other conditions. Raloxifene blocks the effects of the hormone estrogen in the breast and increases the amount of calcium in bone. It is a type of selective estrogen receptor modulator (SERM).

CAS_Registry

84449-90-1

CHEBI_ID

CHEBI:8772

Chemical_Formula

C28H27NO4S

code

C1518

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A selective benzothiophene estrogen receptor modulator (SERM). Raloxifene binds to estrogen receptors (ER) as a mixed estrogen agonist/antagonist; it displays both an ER-alpha-selective partial agonist/antagonist effect and a pure ER-beta-selective antagonist effect. This agent functions as an estrogen agonist in some tissues (bones, lipid metabolism) and as an estrogen antagonist in others (endometrium and breasts), with the potential for producing some of estrogen's beneficial effects without producing its adverse effects. (NCI04)

Display_Name

Raloxifene

FDA_UNII_Code

YX9162EO3I

FULL_SYN

RALOXIFENE

LY 139481

raloxifene

Keoxifene

[6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

Raloxifene

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1762

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38361

label

Raloxifene

Legacy_Concept_Name

Raloxifene

PDQ_Closed_Trial_Search_ID

43109

PDQ_Open_Trial_Search_ID

43109

Preferred_Name

Raloxifene

prefixIRI

ncit:C1518

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0752233

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1821

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http://www.co-ode.org/ontologies/galen#Raloxifene GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0244404 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.150.700.900.775 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00481 FTC LOOM
http://purl.bioontology.org/ontology/UATC/G03XC01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D020849 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/109029006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4024098 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8772 NIFSTD LOOM
http://purl.bioontology.org/ontology/LNC/LP171633-3 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022103 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907039651233937 IOBC LOOM
http://purl.bioontology.org/ontology/CSP/5001-0008 CRISP LOOM
http://purl.jp/bio/4/id/200906030196047290 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#25116 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/72143 RXNORM LOOM