loading...| Preferred Name |
Filgrastim |
|
| Synonyms |
r-metHuG-CSF Tbo-filgrastim Filgrastim-aafi Filgrastim-ayow Recombinant Methionyl Human Granulocyte Colony Stimulating Factor Filgrastim XM02 Tevagrastim Filgrastim Biosimilar Tbo-filgrastim Filgrastim Biosimilar Filgrastim-sndz Filgrastim-sndz FILGRASTIM Filgrastim G-CSF Granix Neupogen Neutroval Nivestym Releuko XM02 Zarxio filgrastim rG-CSF |
|
| Definitions |
A recombinant, non-glycosylated cytokine which is chemically identical to or similar to the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF) isoform B, with immunomodulating activity. Filgrastim binds to and activates G-CSF receptors with the same biological activity and stability as the endogenous cytokine, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1474 |
|
| Accepted_Therapeutic_Use_For |
Aplastic neutropenia; Bone marrow transplantation; Cancer patients receiving myelosuppressive chemotherapy; Congenital neutropenia; Idiopathic or cyclic neutropenia; Peripheral blood progenitor cell mobilization |
|
| ALT_DEFINITION |
A colony-stimulating factor that stimulates the production of neutrophils (a type of white blood cell). It is a cytokine that is a type of hematopoietic (blood-forming) agent. |
|
| CAS_Registry |
121181-53-1 |
|
| code |
C1474 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186329 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
| DEFINITION |
A recombinant, non-glycosylated cytokine which is chemically identical to or similar to the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF) isoform B, with immunomodulating activity. Filgrastim binds to and activates G-CSF receptors with the same biological activity and stability as the endogenous cytokine, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors. |
|
| Display_Name |
Filgrastim |
|
| FDA_UNII_Code |
PVI5M0M1GW |
|
| FULL_SYN |
r-metHuG-CSF Tbo-filgrastim Filgrastim-aafi Filgrastim-ayow Recombinant Methionyl Human Granulocyte Colony Stimulating Factor Filgrastim XM02 Tevagrastim Filgrastim Biosimilar Tbo-filgrastim Filgrastim Biosimilar Filgrastim-sndz Filgrastim-sndz FILGRASTIM Filgrastim G-CSF Granix Neupogen Neutroval Nivestym Releuko XM02 Zarxio filgrastim rG-CSF |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Filgrastim |
|
| Legacy Concept Name |
Filgrastim |
|
| Maps_To |
Filgrastim |
|
| NCI_Drug_Dictionary_ID |
41057 |
|
| PDQ_Closed_Trial_Search_ID |
41057 |
|
| PDQ_Open_Trial_Search_ID |
41057 |
|
| Preferred_Name |
Filgrastim |
|
| prefixIRI |
Thesaurus:C1474 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0210630 |
|
| subClassOf |