Preferred Name |
Imiquimod |
|
Synonyms |
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline 1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)- Aldara IMIQUIMOD Imiquimod R 837 S 26308 Zyclara imiquimod |
|
Definitions |
A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. (NCI04) |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1431 |
|
Accepted_Therapeutic_Use_For |
Condyloma; Superficial Basal Cell Carcinoma; Actinic Keratosis |
|
ALT_DEFINITION |
A drug used to treat early basal cell skin cancer and certain other skin conditions. It is being studied in the treatment of other types of cancer. Imiquimod is a type of biological response modifier. |
|
CAS_Registry |
99011-02-6 |
|
CHEBI_ID |
CHEBI:36704 |
|
Chemical_Formula |
C14H16N4 |
|
code |
C1431 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
Contributing_Source |
CTRP FDA GDC |
|
DEFINITION |
A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. (NCI04) |
|
Display_Name |
Imiquimod |
|
FDA_UNII_Code |
P1QW714R7M |
|
FULL_SYN |
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline 1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)- Aldara IMIQUIMOD Imiquimod R 837 S 26308 Zyclara imiquimod |
|
Is_Value_For_GDC_Property | ||
label |
Imiquimod |
|
Legacy Concept Name |
Imiquimod |
|
Maps_To |
Imiquimod |
|
NCI_Drug_Dictionary_ID |
38558 |
|
NSC Number |
369100 741062 |
|
PDQ_Closed_Trial_Search_ID |
38558 |
|
PDQ_Open_Trial_Search_ID |
38558 |
|
Preferred_Name |
Imiquimod |
|
prefixIRI |
Thesaurus:C1431 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0718327 |
|
subClassOf |