National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Imiquimod

Synonyms

4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline

1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)-

Aldara

IMIQUIMOD

Imiquimod

R 837

S 26308

Zyclara

imiquimod

Definitions

A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1431

Accepted_Therapeutic_Use_For

Condyloma; Superficial Basal Cell Carcinoma; Actinic Keratosis

ALT_DEFINITION

A drug used to treat early basal cell skin cancer and certain other skin conditions. It is being studied in the treatment of other types of cancer. Imiquimod is a type of biological response modifier.

CAS_Registry

99011-02-6

CHEBI_ID

CHEBI:36704

Chemical_Formula

C14H16N4

code

C1431

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

DEFINITION

A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. (NCI04)

Display_Name

Imiquimod

FDA_UNII_Code

P1QW714R7M

FULL_SYN

4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline

1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)-

Aldara

IMIQUIMOD

Imiquimod

R 837

S 26308

Zyclara

imiquimod

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Imiquimod

Legacy Concept Name

Imiquimod

Maps_To

Imiquimod

NCI_Drug_Dictionary_ID

38558

NSC Number

369100

741062

PDQ_Closed_Trial_Search_ID

38558

PDQ_Open_Trial_Search_ID

38558

Preferred_Name

Imiquimod

prefixIRI

Thesaurus:C1431

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0718327

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129820

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/NCIT_C1431 BERO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000038558 PDQ LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148508 NDFRT LOOM
http://purl.bioontology.org/ontology/NDDF/006479 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D000077271 MESH LOOM
http://purl.bioontology.org/ontology/RCD/eiM.. RCD LOOM
http://purl.obolibrary.org/obo/CHEBI_36704 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_36704 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_36704 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_36704 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_36704 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_36704 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_36704 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_36704 HINO LOOM
https://go.drugbank.com/drugs/DB00724 MDM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#18063 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025734 PMAPP-PMO LOOM
http://www.co-ode.org/ontologies/galen#Imiquimod GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386941002 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C056493 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907082151077591 IOBC LOOM
http://purl.jp/bio/4/id/200906048038603786 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/59943 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4021044 VANDF LOOM
http://www.drugbank.ca/drugs/DB00724 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0165032 OCHV LOOM
http://purl.bioontology.org/ontology/ATC/D06BB10 ATC LOOM