National Cancer Institute Thesaurus

Last uploaded: March 26, 2019
Preferred Name

Paclitaxel

Synonyms

[2aR-[2a Alpha,4beta,4a beta,6beta,9alpha(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-(benzoylamino)-alpha-hydroxybenzene-propanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1a,33,4,-41,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-41,8,-12,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester

paclitaxel

Praxel

5Beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one, 4,10-Diacetate 2-Benzoate 13-Ester with (2R,3S)-N-Benzoyl-3-phenylisoserine

PACLITAXEL

Taxol Konzentrat

Taxol

Paclitaxel

Asotax

Anzatax

Bristaxol

Definitions

A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1411

Accepted_Therapeutic_Use_For

AIDS-related Kaposi's sarcoma; Bladder cancer; Breast cancer; Cervical cancer; Endometrial adenocarcinoma; Esophageal cancer; Head and Neck cancer; Lung cancer; non-small cell; Lymphoma; Ovarian cancer; Prostate cancer; Testicular cancer

ALT_DEFINITION

A drug used to treat breast cancer, ovarian cancer, and AIDS-related Kaposi sarcoma. It is also used together with another drug to treat non-small cell lung cancer. Paclitaxel is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of antimitotic agent.

CAS_Registry

33069-62-4

CHEBI_ID

CHEBI:45863

Chemical_Formula

C47H51NO14

code

C1411

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04)

Display_Name

Paclitaxel

FDA_UNII_Code

P88XT4IS4D

FULL_SYN

[2aR-[2a Alpha,4beta,4a beta,6beta,9alpha(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-(benzoylamino)-alpha-hydroxybenzene-propanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1a,33,4,-41,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-41,8,-12,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester

paclitaxel

Praxel

5Beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one, 4,10-Diacetate 2-Benzoate 13-Ester with (2R,3S)-N-Benzoyl-3-phenylisoserine

PACLITAXEL

Taxol Konzentrat

Taxol

Paclitaxel

Asotax

Anzatax

Bristaxol

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18115

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17219

label

Paclitaxel

Legacy_Concept_Name

Paclitaxel

NSC_Code

673089

125973

PDQ_Closed_Trial_Search_ID

39762

PDQ_Open_Trial_Search_ID

39762

Preferred_Name

Paclitaxel

prefixIRI

ncit:C1411

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0144576

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67437

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1490

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