loading...| Preferred Name |
Carbenicillin Indanyl Sodium |
|
| Synonyms |
Carbenicillin Indanyl Sodium CARBENICILLIN INDANYL SODIUM Geocillin |
|
| Definitions |
The sodium salt of indanyl carbenicillin, a broad-spectrum, semi-synthetic carboxypenicillin antibiotic with bactericidal activity. Carbenicillin acylates C-terminal domain of penicillin-sensitive transpeptidase, resulting in opening the lactam ring of the antibiotic. This inactivation prevents the formation of the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. As a result, cell wall integrity is compromised and cell lysis may follow. This agent is used mainly for gram-negative infections, and has limited gram-positive coverage. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1409 |
|
| Accepted_Therapeutic_Use_For |
Urinary tract infections; prostatitis |
|
| CAS_Registry |
26605-69-6 |
|
| CHEBI_ID |
CHEBI:31358 |
|
| Chemical_Formula |
C26H25N2O6S.Na |
|
| code |
C1409 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The sodium salt of indanyl carbenicillin, a broad-spectrum, semi-synthetic carboxypenicillin antibiotic with bactericidal activity. Carbenicillin acylates C-terminal domain of penicillin-sensitive transpeptidase, resulting in opening the lactam ring of the antibiotic. This inactivation prevents the formation of the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. As a result, cell wall integrity is compromised and cell lysis may follow. This agent is used mainly for gram-negative infections, and has limited gram-positive coverage. |
|
| FDA_UNII_Code |
4OUL81K2RT |
|
| FULL_SYN |
Carbenicillin Indanyl Sodium CARBENICILLIN INDANYL SODIUM Geocillin |
|
| label |
Carbenicillin Indanyl Sodium |
|
| Legacy Concept Name |
Carbenicillin_Indanyl_Sodium |
|
| Preferred_Name |
Carbenicillin Indanyl Sodium |
|
| prefixIRI |
Thesaurus:C1409 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0142817 |
|
| subClassOf |