National Cancer Institute Thesaurus

Last uploaded: March 26, 2019
Preferred Name

Carbenicillin Indanyl Sodium

Synonyms

CARBENICILLIN INDANYL SODIUM

Carbenicillin Indanyl Sodium

Geocillin

Definitions

The sodium salt of indanyl carbenicillin, a broad-spectrum, semi-synthetic carboxypenicillin antibiotic with bactericidal activity. Carbenicillin acylates C-terminal domain of penicillin-sensitive transpeptidase, resulting in opening the lactam ring of the antibiotic. This inactivation prevents the formation of the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. As a result, cell wall integrity is compromised and cell lysis may follow. This agent is used mainly for gram-negative infections, and has limited gram-positive coverage.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1409

Accepted_Therapeutic_Use_For

Urinary tract infections; prostatitis

CAS_Registry

26605-69-6

CHEBI_ID

CHEBI:31358

Chemical_Formula

C26H25N2O6S.Na

code

C1409

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The sodium salt of indanyl carbenicillin, a broad-spectrum, semi-synthetic carboxypenicillin antibiotic with bactericidal activity. Carbenicillin acylates C-terminal domain of penicillin-sensitive transpeptidase, resulting in opening the lactam ring of the antibiotic. This inactivation prevents the formation of the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. As a result, cell wall integrity is compromised and cell lysis may follow. This agent is used mainly for gram-negative infections, and has limited gram-positive coverage.

FDA_UNII_Code

4OUL81K2RT

FULL_SYN

CARBENICILLIN INDANYL SODIUM

Carbenicillin Indanyl Sodium

Geocillin

label

Carbenicillin Indanyl Sodium

Legacy_Concept_Name

Carbenicillin_Indanyl_Sodium

Preferred_Name

Carbenicillin Indanyl Sodium

prefixIRI

ncit:C1409

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0142817

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1558

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http://purl.bioontology.org/ontology/VANDF/4018408 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/002702 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/63188000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/SNMI/C-54920 SNMI LOOM
http://purl.bioontology.org/ontology/RXNORM/56461 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146734 NDFRT LOOM