National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Fulvestrant

Synonyms

7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diol

ICI 182780

FULVESTRANT

ICI 182,780

fulvestrant

Faslodex(ICI 182,780)

ZD9238

Fulvestrant

Faslodex

Definitions

A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1379

Accepted_Therapeutic_Use_For

Hormone receptor-positive metastatic breast cancer

ALT_DEFINITION

A drug used to treat certain types of breast cancer in postmenopausal women. It is also being studied in the treatment of other types of cancer. Faslodex blocks estrogen activity in the body and is a type of antiestrogen.

CAS_Registry

129453-61-8

CHEBI_ID

CHEBI:31638

Chemical_Formula

C32H47F5O3S

code

C1379

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04)

Display_Name

Fulvestrant

FDA_UNII_Code

22X328QOC4

FULL_SYN

7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diol

ICI 182780

FULVESTRANT

ICI 182,780

fulvestrant

Faslodex(ICI 182,780)

ZD9238

Fulvestrant

Faslodex

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38361

label

Fulvestrant

Legacy_Concept_Name

Fulvestrant

NSC_Code

719276

PDQ_Closed_Trial_Search_ID

43053

PDQ_Open_Trial_Search_ID

43053

Preferred_Name

Fulvestrant

prefixIRI

ncit:C1379

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0935916

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2116

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://www.drugbank.ca/drugs/DB00947 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/009642 NDDF LOOM
http://purl.obolibrary.org/obo/DRON_00018972 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00018972 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00018972 DRON LOOM
http://purl.bioontology.org/ontology/MESH/D000077267 MESH LOOM
http://purl.bioontology.org/ontology/UATC/L02BA03 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/385519002 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31638 NIFSTD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148770 NDFRT LOOM
http://purl.bioontology.org/ontology/RXNORM/282357 RXNORM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043053 PDQ LOOM
http://purl.bioontology.org/ontology/VANDF/4021350 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C070081 RH-MESH LOOM