National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Doxorubicin Hydrochloride

Synonyms

DOX

hydroxydaunorubicin

Doxorubicin.HCl

Doxorubicin Hydrochloride

L-Lyxo-hexopyranoside, 3b-glycol-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-, hydrochloride

Doxorubicin HCl

Farmiblastina

DOXORUBICIN HYDROCHLORIDE

Doxorubicin hydrochloride

Adrimedac

Doxorubin

Adriblastine

Adriamycin RDF

14-Hydroxydaunorubicin Hydrochloride

ADM

Chloridrato de Doxorrubicina

Adriacin

FI 106

5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)

Adriamycin Hydrochloride

doxorubicin hydrochloride

5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-(9CI)

Adriamycin PFS

Adriamycine

DOXO-CELL

Doxolem

Adriblastina

ADRIAMYCIN, HYDROCHLORIDE

FI-106

Rubex

Adriamycin

Adriamycin hydrochloride

3-Hydroxyacetyldaunorubicin Hydrochloride

Definitions

The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1326

Accepted_Therapeutic_Use_For

Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Wilms' tumor; neuroblastoma; soft tissue and bone sarcomas; small cell carcinoma of the lung; lymphomas; multiple myeloma; mesotheliomas; germ cell tumors of the ovary or testis.

Carcinomas of breast, thyroid, gastric, ovarian, bronchogenic, head and neck, prostate, cervical, pancreatic, uterine, hepatic, and transitional cell bladder carcinomas.

ALT_DEFINITION

A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Adriamycin PFS comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic.

CAS_Registry

25316-40-9

Chemical_Formula

C27H29NO11.HCl

code

C1326

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.

Display_Name

Doxorubicin Hydrochloride

FDA_UNII_Code

82F2G7BL4E

FULL_SYN

DOX

hydroxydaunorubicin

Doxorubicin.HCl

Doxorubicin Hydrochloride

L-Lyxo-hexopyranoside, 3b-glycol-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-, hydrochloride

Doxorubicin HCl

Farmiblastina

DOXORUBICIN HYDROCHLORIDE

Doxorubicin hydrochloride

Adrimedac

Doxorubin

Adriblastine

Adriamycin RDF

14-Hydroxydaunorubicin Hydrochloride

ADM

Chloridrato de Doxorrubicina

Adriacin

FI 106

5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)

Adriamycin Hydrochloride

doxorubicin hydrochloride

5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-(9CI)

Adriamycin PFS

Adriamycine

DOXO-CELL

Doxolem

Adriblastina

ADRIAMYCIN, HYDROCHLORIDE

FI-106

Rubex

Adriamycin

Adriamycin hydrochloride

3-Hydroxyacetyldaunorubicin Hydrochloride

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C456

label

Doxorubicin Hydrochloride

Legacy_Concept_Name

Doxorubicin_Hydrochloride

NSC_Code

123127

PDQ_Closed_Trial_Search_ID

38860

PDQ_Open_Trial_Search_ID

38860

Preferred_Name

Doxorubicin Hydrochloride

prefixIRI

ncit:C1326

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0546861

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67502

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNMI/C-780C1 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4018106 VANDF LOOM
http://www.co-ode.org/ontologies/galen#DoxorubicinHydrochloride GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/90875009 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_31522 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31522 CHEBI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#38850 OCHV LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000038860 PDQ LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146444 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0546861 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/142433 RXNORM LOOM