loading...| Preferred Name |
Tacrolimus |
|
| Synonyms |
Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone FK 506 FK-506 Fujimycin Hecoria Prograf Protopic TACROLIMUS Tacforius Tacrolimus tacrolimus |
|
| Definitions |
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311 |
|
| Accepted_Therapeutic_Use_For |
Atopic dermatitis; Kidney transplant rejection, prophylaxis; Liver transplant rejection, prophylaxis |
|
| ALT_DEFINITION |
A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants. |
|
| CAS_Registry |
109581-93-3 |
|
| CHEBI_ID |
CHEBI:61057 |
|
| Chemical_Formula |
C44H69NO12.H2O |
|
| code |
C1311 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. |
|
| Display_Name |
Tacrolimus |
|
| FDA_UNII_Code |
WM0HAQ4WNM |
|
| FULL_SYN |
Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone FK 506 FK-506 Fujimycin Hecoria Prograf Protopic TACROLIMUS Tacforius Tacrolimus tacrolimus |
|
| Has_Target | ||
| label |
Tacrolimus |
|
| Legacy Concept Name |
Tacrolimus |
|
| NCI_Drug_Dictionary_ID |
42009 |
|
| NSC Number |
717865 |
|
| PDQ_Closed_Trial_Search_ID |
42009 |
|
| PDQ_Open_Trial_Search_ID |
42009 |
|
| Preferred_Name |
Tacrolimus |
|
| prefixIRI |
Thesaurus:C1311 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0085149 |
|
| subClassOf |