loading...| Preferred Name |
Carboplatin |
|
| Synonyms |
Carboplatin Hexal Carboplatin Paraplatine cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II) Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum Carboplatinum Novoplatinum Paraplatin AQ carboplatin CARBOPLATIN 1,1-cyclobutanedicarboxylic acid platinum complex (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum Carboplatino platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2) cis-diammine(cyclobutanedicarboxylato)platinum II Blastocarb CBDCA Carboplat Carbosin Carbosol Carbotec Displata Ercar JM-8 JM8 Nealorin Paraplat Paraplatin Platinwas Ribocarbo |
|
| Definitions |
A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 |
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| Accepted_Therapeutic_Use_For |
Osteogenic sarcoma; CNS and germ cell tumors; ovarian; lung; head and neck; endometrial; esophageal; bladder; breast; cervical cancer. |
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| ALT_DEFINITION |
A drug that is used to treat advanced ovarian cancer that has never been treated or symptoms of ovarian cancer that has come back after treatment with other anticancer drugs. It is also used with other drugs to treat advanced, metastatic, or recurrent non-small cell lung cancer and is being studied in the treatment of other types of cancer. Paraplatin is a form of the anticancer drug cisplatin and causes fewer side effects in patients. It attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound. |
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| CAS_Registry |
41575-94-4 |
|
| CHEBI_ID |
CHEBI:31355 |
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| Chemical_Formula |
C6H6O4.Pt.2H3N |
|
| code |
C1282 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179531 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc OORO PCDC |
|
| DEFINITION |
A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04) |
|
| Display_Name |
Carboplatin |
|
| FDA_UNII_Code |
BG3F62OND5 |
|
| FULL_SYN |
Carboplatin Hexal Carboplatin Paraplatine cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II) Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum Carboplatinum Novoplatinum Paraplatin AQ carboplatin CARBOPLATIN 1,1-cyclobutanedicarboxylic acid platinum complex (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum Carboplatino platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2) cis-diammine(cyclobutanedicarboxylato)platinum II Blastocarb CBDCA Carboplat Carbosin Carbosol Carbotec Displata Ercar JM-8 JM8 Nealorin Paraplat Paraplatin Platinwas Ribocarbo |
|
| Is_PCDC_GCT_Authorized_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Carboplatin |
|
| Legacy Concept Name |
Carboplatin |
|
| Maps_To |
Carboplatin |
|
| NCI_Drug_Dictionary_ID |
39176 |
|
| NSC Number |
201345 241240 |
|
| PDQ_Closed_Trial_Search_ID |
39176 |
|
| PDQ_Open_Trial_Search_ID |
39176 |
|
| Preferred_Name |
Carboplatin |
|
| prefixIRI |
Thesaurus:C1282 |
|
| Semantic_Type |
Pharmacologic Substance Inorganic Chemical |
|
| UMLS_CUI |
C0079083 |
|
| subClassOf |