National Cancer Institute Thesaurus

Last uploaded: July 29, 2019
Preferred Name

Carboplatin

Synonyms

carboplatin

Platinwas

Carbotec

1,1-cyclobutanedicarboxylic acid platinum complex

Carboplatin Hexal

platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2)

Carboplat

Blastocarb

Paraplatin AQ

(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum

Paraplat

Ribocarbo

Carbosin

cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II)

Carboplatinum

cis-diammine(cyclobutanedicarboxylato)platinum II

Displata

Paraplatin

CBDCA

CARBOPLATIN

Nealorin

Carbosol

Paraplatine

Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum

Ercar

Carboplatino

JM-8

Novoplatinum

Carboplatin

Definitions

A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282

Accepted_Therapeutic_Use_For

Osteogenic sarcoma; CNS and germ cell tumors; ovarian; lung; head and neck; endometrial; esophageal; bladder; breast; cervical cancer.

ALT_DEFINITION

A drug that is used to treat advanced ovarian cancer that has never been treated or symptoms of ovarian cancer that has come back after treatment with other anticancer drugs. It is also used with other drugs to treat advanced, metastatic, or recurrent non-small cell lung cancer and is being studied in the treatment of other types of cancer. Paraplatin is a form of the anticancer drug cisplatin and causes fewer side effects in patients. It attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound.

CAS_Registry

41575-94-4

CHEBI_ID

CHEBI:31355

Chemical_Formula

C6H6O4.Pt.2H3N

code

C1282

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)

Display_Name

Carboplatin

FDA_UNII_Code

BG3F62OND5

FULL_SYN

carboplatin

Platinwas

Carbotec

1,1-cyclobutanedicarboxylic acid platinum complex

Carboplatin Hexal

platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2)

Carboplat

Blastocarb

Paraplatin AQ

(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum

Paraplat

Ribocarbo

Carbosin

cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II)

Carboplatinum

cis-diammine(cyclobutanedicarboxylato)platinum II

Displata

Paraplatin

CBDCA

CARBOPLATIN

Nealorin

Carbosol

Paraplatine

Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum

Ercar

Carboplatino

JM-8

Novoplatinum

Carboplatin

label

Carboplatin

Legacy_Concept_Name

Carboplatin

NSC_Code

201345

241240

PDQ_Closed_Trial_Search_ID

39176

PDQ_Open_Trial_Search_ID

39176

Preferred_Name

Carboplatin

prefixIRI

ncit:C1282

Semantic_Type

Pharmacologic Substance

Inorganic Chemical

UMLS_CUI

C0079083

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1450

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016190 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.691.800.338 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002643 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D016190 MESH LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_31355 NPO LOOM
http://www.ifomis.org/acgt/1.0#Carboplatin ACGT-MO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_31355 EFO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386905002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/40048 RXNORM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039176 PDQ LOOM
http://purl.bioontology.org/ontology/CSP/4007-0021 CRISP LOOM
http://purl.bioontology.org/ontology/UATC/L01XA02 ATC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 ROO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1282 ROO SAME_URI
http://purl.bioontology.org/ontology/RCD/h52.. RCD LOOM
http://www.co-ode.org/ontologies/galen#Carboplatin GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4019478 VANDF LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147598 ODAE LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147598 NDFRT LOOM
http://purl.jp/bio/4/id/200906057373397197 IOBC LOOM
http://purl.jp/bio/4/id/200906057373397197 IOBC LOOM
http://purl.jp/bio/4/id/200906057373397197 IOBC LOOM