loading...| Preferred Name |
Toremifene |
|
| Synonyms |
(Z)-4-Chloro-1,2-diphenyl-1[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-1-butene (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine Farestone TOREMIFENE Toremifene toremifene |
|
| Definitions |
A nonsteroidal triphenylethylene antiestrogen. Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM). This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity. Toremifene also has intrinsic estrogenic properties, which are manifested according to tissue type or species. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1256 |
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| Accepted_Therapeutic_Use_For |
Breast cancer; Desmoid tumors |
|
| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antiestrogens. Toremifene blocks the effect of the hormone estrogen in the body. It may help control some cancers from growing, and it may delay or reduce the risk of cancer recurrence. |
|
| CAS_Registry |
89778-26-7 |
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| CHEBI_ID |
CHEBI:9635 |
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| Chemical_Formula |
C26H28ClNO |
|
| code |
C1256 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC HemOnc |
|
| DEFINITION |
A nonsteroidal triphenylethylene antiestrogen. Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM). This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity. Toremifene also has intrinsic estrogenic properties, which are manifested according to tissue type or species. (NCI04) |
|
| FDA_UNII_Code |
7NFE54O27T |
|
| FULL_SYN |
(Z)-4-Chloro-1,2-diphenyl-1[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-1-butene (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine Farestone TOREMIFENE Toremifene toremifene |
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| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Toremifene |
|
| Legacy Concept Name |
Toremifene |
|
| Maps_To |
Toremifene |
|
| NCI_Drug_Dictionary_ID |
41103 |
|
| PDQ_Closed_Trial_Search_ID |
41103 |
|
| PDQ_Open_Trial_Search_ID |
41103 |
|
| Preferred_Name |
Toremifene |
|
| prefixIRI |
Thesaurus:C1256 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0076836 |
|
| subClassOf |