National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Temozolomide

Synonyms

TEMOZOLOMIDE

8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one

Methazolastone

3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide

M and B 39831

temozolomide

CCRG-81045

Temomedac

TMZ

SCH 52365

imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-

RP-46161

Temcad

Temozolomide

Temodar

Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-

Temodal

M & B 39831

Definitions

A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1244

Accepted_Therapeutic_Use_For

Malignant glioma (Anaplastic astrocytoma; Anaplastic oligodendrogliomas; Anaplastic oligoastrocytomas; Glioblastoma multiforme); Metastatic melanoma

ALT_DEFINITION

A drug that is used to treat certain types of brain tumors in adults and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents.

CAS_Registry

85622-93-1

Chemical_Formula

C6H6N6O2

code

C1244

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. (NCI04)

Display_Name

Temozolomide

FDA_UNII_Code

YF1K15M17Y

FULL_SYN

TEMOZOLOMIDE

8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one

Methazolastone

3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide

M and B 39831

temozolomide

CCRG-81045

Temomedac

TMZ

SCH 52365

imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-

RP-46161

Temcad

Temozolomide

Temodar

Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-

Temodal

M & B 39831

label

Temozolomide

Legacy_Concept_Name

Temozolomide

NSC_Code

362856

PDQ_Closed_Trial_Search_ID

41671

PDQ_Open_Trial_Search_ID

41671

Preferred_Name

Temozolomide

prefixIRI

ncit:C1244

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0076080

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C902

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http://purl.bioontology.org/ontology/UATC/L01AX03 ATC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041671 PDQ LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14908 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D000077204 MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 CHEBI LOOM
http://purl.bioontology.org/ontology/NDDF/007794 NDDF LOOM
http://purl.jp/bio/4/id/200906010256487782 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148622 NDFRT LOOM
http://purl.obolibrary.org/obo/DRON_00017608 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00017608 DRON LOOM
http://www.ifomis.org/acgt/1.0#Temozolomide ACGT-MO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387009002 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0076080 OCHV LOOM
http://purl.bioontology.org/ontology/CSP/4008-0098 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/37776 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Temozolomide GALEN LOOM
http://stirdf.jst.go.jp/id/200907074216809916 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C047246 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4021173 VANDF LOOM