National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Xanthohumol

Synonyms

XANTHOHUMOL

Xanthohumol

3'-[3,3-Dimethyl allyl]-2',4',4-trihydroxy-6'-methoxychalcone

Definitions

A prenylated flavonoid derived from the female flowers of the hops plant (Humulus lupulus L), with potential chemopreventive and antineoplastic activities. Upon administration, xanthohumol scavenges reactive oxygen species (ROS), thereby preventing DNA damage due to oxidative stress. In addition, xanthohumol is able to increase the expression of phase II cytoprotective enzymes, thereby inactivating carcinogens. This agent exerts anti-inflammatory activity, through the inhibition of inflammation-inducing enzymes, inhibits DNA synthesis, and induces apoptosis of susceptible cancer cells. Xanthohumol also decreases the expression of C-X-C chemokine receptor 4 (CXCR4), thereby preventing cancer cell invasion.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C121950

CAS_Registry

6754-58-1

code

C121950

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

FDA

GDC

DEFINITION

A prenylated flavonoid derived from the female flowers of the hops plant (Humulus lupulus L), with potential chemopreventive and antineoplastic activities. Upon administration, xanthohumol scavenges reactive oxygen species (ROS), thereby preventing DNA damage due to oxidative stress. In addition, xanthohumol is able to increase the expression of phase II cytoprotective enzymes, thereby inactivating carcinogens. This agent exerts anti-inflammatory activity, through the inhibition of inflammation-inducing enzymes, inhibits DNA synthesis, and induces apoptosis of susceptible cancer cells. Xanthohumol also decreases the expression of C-X-C chemokine receptor 4 (CXCR4), thereby preventing cancer cell invasion.

FDA_UNII_Code

T4467YT1NT

FULL_SYN

XANTHOHUMOL

Xanthohumol

3'-[3,3-Dimethyl allyl]-2',4',4-trihydroxy-6'-methoxychalcone

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Xanthohumol

Maps_To

Xanthohumol

NCI_Drug_Dictionary_ID

772021

PDQ_Closed_Trial_Search_ID

772021

PDQ_Open_Trial_Search_ID

772021

Preferred_Name

Xanthohumol

prefixIRI

Thesaurus:C121950

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0536128

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1892

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C107589

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