National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ketorolac

Synonyms

KETOROLAC

Ketorolac

ketorolac

Definitions

A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. The inhibition of COX-1 by this agent prevents the normal steady-state production of prostaglandins that play housekeeping roles in the protection of the gastrointestinal tract, the regulation of renal blood flow, and platelet aggregation. As a result, the inhibition of COX-1 may be associated with gastrointestinal toxicity, nephrotoxicity, and the inhibition of platelet aggregation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1219

CAS_Registry

74103-06-3

Chemical_Formula

C15H13NO3

code

C1219

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. The inhibition of COX-1 by this agent prevents the normal steady-state production of prostaglandins that play housekeeping roles in the protection of the gastrointestinal tract, the regulation of renal blood flow, and platelet aggregation. As a result, the inhibition of COX-1 may be associated with gastrointestinal toxicity, nephrotoxicity, and the inhibition of platelet aggregation.

Display_Name

Ketorolac

FDA_UNII_Code

YZI5105V0L

FULL_SYN

KETOROLAC

Ketorolac

ketorolac

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61798

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17984

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19705

label

Ketorolac

Legacy Concept Name

Ketorolac

NCI_Drug_Dictionary_ID

40569

PDQ_Closed_Trial_Search_ID

40569

PDQ_Open_Trial_Search_ID

40569

Preferred_Name

Ketorolac

prefixIRI

Thesaurus:C1219

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0073631

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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Delete Mapping To Ontology Source
http://purl.jp/bio/4/id/200906003996940140 IOBC LOOM
http://purl.obolibrary.org/obo/MESH_D020910 BERO LOOM
http://www.drugbank.ca/drugs/DB00465 FTC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000178380 NDFRT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017710 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D020910 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/x01L6 RCD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372501008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/M01AB15 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/35827 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.473.420.485 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14770 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0020734 OMIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0073631 OCHV LOOM
http://id.nlm.nih.gov/mesh/D020910 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007199 LOINC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040569 PDQ LOOM
http://scai.fraunhofer.de/AlzheimerOntology#ketorolac ADO LOOM
http://purl.bioontology.org/ontology/LNC/LP18986-7 LOINC LOOM
https://go.drugbank.com/drugs/DB00465 MDM LOOM
http://www.co-ode.org/ontologies/galen#Ketorolac GALEN LOOM
http://purl.obolibrary.org/obo/dinto_DB00465 DINTO LOOM
http://purl.bioontology.org/ontology/VANDF/4028637 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_6129 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6129 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6129 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6129 CHEBI LOOM
http://purl.bioontology.org/ontology/MESH/D020910 MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C1219 BERO LOOM
http://stirdf.jst.go.jp/id/200907064796679741 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/S01BC05 ATC LOOM
http://purl.bioontology.org/ontology/NDDF/004812 NDDF LOOM