Preferred Name |
Ketorolac |
|
Synonyms |
KETOROLAC Ketorolac ketorolac |
|
Definitions |
A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. The inhibition of COX-1 by this agent prevents the normal steady-state production of prostaglandins that play housekeeping roles in the protection of the gastrointestinal tract, the regulation of renal blood flow, and platelet aggregation. As a result, the inhibition of COX-1 may be associated with gastrointestinal toxicity, nephrotoxicity, and the inhibition of platelet aggregation. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1219 |
|
CAS_Registry |
74103-06-3 |
|
Chemical_Formula |
C15H13NO3 |
|
code |
C1219 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
Contributing_Source |
CTRP FDA |
|
DEFINITION |
A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. The inhibition of COX-1 by this agent prevents the normal steady-state production of prostaglandins that play housekeeping roles in the protection of the gastrointestinal tract, the regulation of renal blood flow, and platelet aggregation. As a result, the inhibition of COX-1 may be associated with gastrointestinal toxicity, nephrotoxicity, and the inhibition of platelet aggregation. |
|
Display_Name |
Ketorolac |
|
FDA_UNII_Code |
YZI5105V0L |
|
FULL_SYN |
KETOROLAC Ketorolac ketorolac |
|
Has_Salt_Form | ||
Has_Target | ||
label |
Ketorolac |
|
Legacy Concept Name |
Ketorolac |
|
NCI_Drug_Dictionary_ID |
40569 |
|
PDQ_Closed_Trial_Search_ID |
40569 |
|
PDQ_Open_Trial_Search_ID |
40569 |
|
Preferred_Name |
Ketorolac |
|
prefixIRI |
Thesaurus:C1219 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0073631 |
|
subClassOf |