loading...| Preferred Name |
Dolutegravir |
|
| Synonyms |
Dolutegravir GSK-1349572 DOLUTEGRAVIR 2H-Pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide, N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS) GSK 1349572 DTG |
|
| Definitions |
An orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This prevents HIV-1 replication. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C121543 |
|
| CAS_Registry |
1051375-16-6 |
|
| code |
C121543 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
An orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This prevents HIV-1 replication. |
|
| Display_Name |
Dolutegravir |
|
| FDA_UNII_Code |
DKO1W9H7M1 |
|
| FULL_SYN |
Dolutegravir GSK-1349572 DOLUTEGRAVIR 2H-Pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide, N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS) GSK 1349572 DTG |
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| Has_Salt_Form | ||
| label |
Dolutegravir |
|
| NCI_Drug_Dictionary_ID |
770209 |
|
| PDQ_Closed_Trial_Search_ID |
770209 |
|
| PDQ_Open_Trial_Search_ID |
770209 |
|
| Preferred_Name |
Dolutegravir |
|
| prefixIRI |
Thesaurus:C121543 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C3253985 |
|
| subClassOf |