loading...| Preferred Name |
Dalbavancin |
|
| Synonyms |
Dalbavancin Ristomycin A Aglycone, 5,31-Dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-O-(2-deoxy-2-((10-methyl-1-oxoundecyl)amino)-beta-D-glucopyranuronosyl)-38-(((3-(dimethylamino)propyl)amino)carbonyl)-42-O-alpha-D-mannopyranosyl-N15-methyl- DALBAVANCIN Dalvance MDL 63,397 VER001 |
|
| Definitions |
A second-generation, semi-synthetic lipoglycopeptide antibiotic, with bactericidal activity against a variety of gram-positive bacteria. Upon administration, dalbavancin binds, at a site different from that of penicillins and cephalosporins, tightly to the D-alanyl-D-alanine portion of peptidoglycan chains, thereby preventing peptidoglycan elongation and interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins and induces cell wall lysis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116741 |
|
| CAS_Registry |
171500-79-1 |
|
| code |
C116741 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A second-generation, semi-synthetic lipoglycopeptide antibiotic, with bactericidal activity against a variety of gram-positive bacteria. Upon administration, dalbavancin binds, at a site different from that of penicillins and cephalosporins, tightly to the D-alanyl-D-alanine portion of peptidoglycan chains, thereby preventing peptidoglycan elongation and interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins and induces cell wall lysis. |
|
| Display_Name |
Dalbavancin |
|
| FDA_UNII_Code |
808UI9MS5K |
|
| FULL_SYN |
Dalbavancin Ristomycin A Aglycone, 5,31-Dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-O-(2-deoxy-2-((10-methyl-1-oxoundecyl)amino)-beta-D-glucopyranuronosyl)-38-(((3-(dimethylamino)propyl)amino)carbonyl)-42-O-alpha-D-mannopyranosyl-N15-methyl- DALBAVANCIN Dalvance MDL 63,397 VER001 |
|
| label |
Dalbavancin |
|
| NCI_Drug_Dictionary_ID |
682691 |
|
| PDQ_Closed_Trial_Search_ID |
682691 |
|
| PDQ_Open_Trial_Search_ID |
682691 |
|
| Preferred_Name |
Dalbavancin |
|
| prefixIRI |
Thesaurus:C116741 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0911853 |
|
| subClassOf |