National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Chlorogenic Acid

Synonyms

CHLOROGENIC ACID

3-Caffeoylquinic Acid

Chlorogenic Acid

5-O-(3,4-Dihydroxycinnamoyl)-L-quinic Acid

Definitions

A polyphenol and the ester of caffeic acid and quinic acid that is found in coffee and black tea, with potential antioxidant and chemopreventive activities. Chlorogenic acid scavenges free radicals, which inhibits DNA damage and may protect against the induction of carcinogenesis. In addition, this agent may upregulate the expression of genes involved in the activation of the immune system and enhances activation and proliferation of cytotoxic T-lymphocytes, macrophages, and natural killer cells. Chlorogenic acid also inhibits the activity of matrix metalloproteinases.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116073

CAS_Registry

327-97-9

code

C116073

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A polyphenol and the ester of caffeic acid and quinic acid that is found in coffee and black tea, with potential antioxidant and chemopreventive activities. Chlorogenic acid scavenges free radicals, which inhibits DNA damage and may protect against the induction of carcinogenesis. In addition, this agent may upregulate the expression of genes involved in the activation of the immune system and enhances activation and proliferation of cytotoxic T-lymphocytes, macrophages, and natural killer cells. Chlorogenic acid also inhibits the activity of matrix metalloproteinases.

FDA_UNII_Code

318ADP12RI

FULL_SYN

CHLOROGENIC ACID

3-Caffeoylquinic Acid

Chlorogenic Acid

5-O-(3,4-Dihydroxycinnamoyl)-L-quinic Acid

label

Chlorogenic Acid

NCI_Drug_Dictionary_ID

761171

PDQ_Closed_Trial_Search_ID

761171

PDQ_Open_Trial_Search_ID

761171

Preferred_Name

Chlorogenic Acid

prefixIRI

Thesaurus:C116073

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0008240

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28203

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