loading...| Preferred Name |
Fludarabine Phosphate |
|
| Synonyms |
Fludarabine Phosphate fludarabine phosphate 2-F-ara-AMP FLUDARABINE PHOSPHATE 9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl) Fludarabine-5'-Monophosphate 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)- Beneflur Fludara Oforta SH T 586 |
|
| Definitions |
The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1102 |
|
| Accepted_Therapeutic_Use_For |
Chronic Lymphocytic Leukemia |
|
| ALT_DEFINITION |
A drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anticancer drugs or that has gotten worse. It is also being studied in the treatment of other types of cancer. Fludara blocks cells from making DNA and may kill cancer cells. It is a type of purine antagonist and a type of ribonucleotide reductase inhibitor. |
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| CAS_Registry |
75607-67-9 |
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| CHEBI_ID |
CHEBI:63599 |
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| Chemical_Formula |
C10H13FN5O7P |
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| code |
C1102 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. |
|
| Display_Name |
Fludarabine Phosphate |
|
| FDA_UNII_Code |
1X9VK9O1SC |
|
| FULL_SYN |
Fludarabine Phosphate fludarabine phosphate 2-F-ara-AMP FLUDARABINE PHOSPHATE 9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl) Fludarabine-5'-Monophosphate 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)- Beneflur Fludara Oforta SH T 586 |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16510 |
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| Is_Value_For_GDC_Property | ||
| label |
Fludarabine Phosphate |
|
| Legacy Concept Name |
Fludarabine_Phosphate |
|
| Maps_To |
Fludarabine Phosphate |
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| NCI_Drug_Dictionary_ID |
486428 |
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| NSC Number |
312887 328002 |
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| PDQ_Closed_Trial_Search_ID |
486428 |
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| PDQ_Open_Trial_Search_ID |
486428 |
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| Preferred_Name |
Fludarabine Phosphate |
|
| prefixIRI |
Thesaurus:C1102 |
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
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| UMLS_CUI |
C0060483 |
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| subClassOf |