National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Cefixime

Synonyms

Suprax

Cefixime

CEFIXIME

cefixime

FK 027

Definitions

A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1100

ALT_DEFINITION

An antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporins.

CAS_Registry

79350-37-1

CHEBI_ID

CHEBI:472657

Chemical_Formula

C16H15N5O7S2.3H2O

code

C1100

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins.

Display_Name

Cefixime

FDA_UNII_Code

97I1C92E55

FULL_SYN

Suprax

Cefixime

CEFIXIME

cefixime

FK 027

label

Cefixime

Legacy_Concept_Name

Cefixime

PDQ_Closed_Trial_Search_ID

37809

PDQ_Open_Trial_Search_ID

37809

Preferred_Name

Cefixime

prefixIRI

ncit:C1100

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0060400

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

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http://www.co-ode.org/ontologies/galen#Cefixime GALEN LOOM
http://purl.bioontology.org/ontology/NDDF/002737 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D020682 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/J01DD08 ATC LOOM
http://purl.bioontology.org/ontology/LNC/LP17701-1 LOINC LOOM
http://purl.jp/bio/4/id/200906065371368125 IOBC LOOM
http://purl.jp/bio/4/id/200906065371368125 IOBC LOOM
http://purl.jp/bio/4/id/200906065371368125 IOBC LOOM
http://purl.jp/bio/4/id/200906065371368125 IOBC LOOM
http://purl.obolibrary.org/obo/DRON_00017900 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147544 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907019822783727 IOBC LOOM
http://stirdf.jst.go.jp/id/200907019822783727 IOBC LOOM
http://stirdf.jst.go.jp/id/200907019822783727 IOBC LOOM
http://stirdf.jst.go.jp/id/200907019822783727 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.190.190.115 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D020682 MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000037809 PDQ LOOM
http://purl.bioontology.org/ontology/RXNORM/25033 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU005580 LOINC LOOM
http://purl.obolibrary.org/obo/ARO_3000646 ARO LOOM
http://purl.obolibrary.org/obo/ARO_3000646 ARO LOOM
http://purl.bioontology.org/ontology/SNMI/C-535C0 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4019391 VANDF LOOM
http://purl.bioontology.org/ontology/RCD/e6h.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.190.190.115 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_472657 NIFSTD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387536009 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.190.190.115 RH-MESH LOOM