Preferred Name |
Cefixime |
|
Synonyms |
Cefixime Trihydrate CEFIXIME Cefixime FK 027 Suprax cefixime |
|
Definitions |
A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1100 |
|
ALT_DEFINITION |
An antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporins. |
|
CAS_Registry |
125110-14-7 |
|
CHEBI_ID |
CHEBI:472657 |
|
Chemical_Formula |
C16H15N5O7S2.3H2O |
|
code |
C1100 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
Contributing_Source |
CTRP FDA HemOnc |
|
DEFINITION |
A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins. |
|
Display_Name |
Cefixime |
|
FDA_UNII_Code |
97I1C92E55 |
|
FULL_SYN |
Cefixime Trihydrate CEFIXIME Cefixime FK 027 Suprax cefixime |
|
Has_Salt_Form | ||
label |
Cefixime |
|
Legacy Concept Name |
Cefixime |
|
NCI_Drug_Dictionary_ID |
37809 |
|
PDQ_Closed_Trial_Search_ID |
37809 |
|
PDQ_Open_Trial_Search_ID |
37809 |
|
Preferred_Name |
Cefixime |
|
prefixIRI |
Thesaurus:C1100 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
UMLS_CUI |
C0060400 |
|
subClassOf |