loading...| Preferred Name |
Finasteride |
|
| Synonyms |
Chibro-Proscar Finasteride FINASTERIDE finasteride (5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide Finastid MK 906 Pro-Cure Propecia Propeshia Proscar Prostide Urprosan |
|
| Definitions |
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1099 |
|
| ALT_DEFINITION |
A drug used to reduce the amount of male hormone (testosterone) produced by the body. |
|
| CAS_Registry |
98319-26-7 |
|
| CHEBI_ID |
CHEBI:5062 |
|
| Chemical_Formula |
C23H36N2O2 |
|
| code |
C1099 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. |
|
| Display_Name |
Finasteride |
|
| FDA_UNII_Code |
57GNO57U7G |
|
| FULL_SYN |
Chibro-Proscar Finasteride FINASTERIDE finasteride (5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide Finastid MK 906 Pro-Cure Propecia Propeshia Proscar Prostide Urprosan |
|
| Has_Target | ||
| label |
Finasteride |
|
| Legacy Concept Name |
Finasteride |
|
| NCI_Drug_Dictionary_ID |
41096 |
|
| PDQ_Closed_Trial_Search_ID |
41096 |
|
| PDQ_Open_Trial_Search_ID |
41096 |
|
| Preferred_Name |
Finasteride |
|
| prefixIRI |
Thesaurus:C1099 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0060389 |
|
| subClassOf |