National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Budesonide

Synonyms

Pulmicort Turbuhaler

(RS)-11beta,16alpha,17,21,-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w/ Butyraldehyde

Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-

BUDESONIDE

Budecort

Budesonide

Butacort

Eltair

Nasocort

Preferid

Pulmicort

Rhinocort

budesonide

Definitions

A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon administration, budesonide binds to intracellular glucocorticoid receptors (GRs) and induces the expression of glucocorticoid-responsive genes that encode for anti-inflammatory mediators, such as certain anti-inflammatory cytokines, including interleukin 10 (IL-10), and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, budesonide prevents the release of pro-inflammatory cytokines from epithelial cells and macrophages, including interleukin 6 (IL-6), IL-8, interferon-beta (IFNb), and inhibits nuclear factor kappa-B (NF-kB) activation thereby decreasing NF-kB-mediated inflammation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1027

ALT_DEFINITION

A drug used in the treatment of asthma and rhinitis. It is also being studied in the treatment of cancer. Budesonide belongs to the family of drugs called steroids.

CAS_Registry

51333-22-3

CHEBI_ID

CHEBI:3207

code

C1027

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon administration, budesonide binds to intracellular glucocorticoid receptors (GRs) and induces the expression of glucocorticoid-responsive genes that encode for anti-inflammatory mediators, such as certain anti-inflammatory cytokines, including interleukin 10 (IL-10), and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, budesonide prevents the release of pro-inflammatory cytokines from epithelial cells and macrophages, including interleukin 6 (IL-6), IL-8, interferon-beta (IFNb), and inhibits nuclear factor kappa-B (NF-kB) activation thereby decreasing NF-kB-mediated inflammation.

Display_Name

Budesonide

FDA_UNII_Code

Q3OKS62Q6X

FULL_SYN

Pulmicort Turbuhaler

(RS)-11beta,16alpha,17,21,-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w/ Butyraldehyde

Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-

BUDESONIDE

Budecort

Budesonide

Butacort

Eltair

Nasocort

Preferid

Pulmicort

Rhinocort

budesonide

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17071

label

Budesonide

Legacy Concept Name

Budesonide

Preferred_Name

Budesonide

prefixIRI

Thesaurus:C1027

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0054201

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C521

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/ATC/R03BA02 ATC LOOM
http://stirdf.jst.go.jp/id/200907022283134605 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/R01AD05 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.745.654.105 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4020889 VANDF LOOM
http://purl.obolibrary.org/obo/MESH_D019819 BERO LOOM
https://go.drugbank.com/drugs/DB01222 MDM LOOM
http://purl.obolibrary.org/obo/CHEBI_3207 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_3207 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3207 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3207 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3207 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3207 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3207 NIFSTD LOOM
http://purl.bioontology.org/ontology/MESH/D019819 MESH LOOM
http://purl.bioontology.org/ontology/ATC/A07EA06 ATC LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass94e0f9e5_5165_4ea3_a99e_a96d3c37d60a WWECA LOOM
http://purl.bioontology.org/ontology/LNC/MTHU017344 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Budesonide GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/395726003 SNOMEDCT LOOM
http://www.drugbank.ca/drugs/DB01222 FTC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018734 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/ATC/D07AC09 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13628 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0054201 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/19831 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C1027 BERO LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00934 COID LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D019819 RH-MESH LOOM
http://purl.jp/bio/4/id/200906051415021763 IOBC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043267 PDQ LOOM
http://purl.bioontology.org/ontology/LNC/LP35867-8 LOINC LOOM
http://purl.obolibrary.org/obo/OMIT_0019800 OMIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148384 NDFRT LOOM
http://purl.bioontology.org/ontology/NDDF/004214 NDDF LOOM