National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Sofosbuvir

Synonyms

L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl Ester

GS-7977

PSI-7977

SOFOSBUVIR

Sofosbuvir

Definitions

An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101263

CAS_Registry

1190307-88-0

Chemical_Formula

C22H29FN3O9P

code

C101263

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome.

Display_Name

Sofosbuvir

FDA_UNII_Code

WJ6CA3ZU8B

FULL_SYN

L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl Ester

GS-7977

PSI-7977

SOFOSBUVIR

Sofosbuvir

label

Sofosbuvir

NCI_Drug_Dictionary_ID

729636

PDQ_Closed_Trial_Search_ID

729636

PDQ_Open_Trial_Search_ID

729636

Preferred_Name

Sofosbuvir

prefixIRI

Thesaurus:C101263

PubMedID_Primary_Reference

20845908

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C2976303

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C281

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25995

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