Medical Subject Headings

Last uploaded: August 27, 2019
Preferred Name

Simvastatin

Synonyms

MK-733

Definitions

A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.

ID

http://purl.bioontology.org/ontology/MESH/D019821

altLabel

MK-733

MK733

MK 733

Zocor

Synvinolin

AQL

AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR

cui

C0074554

C4082576

C0678181

C0733683

DC

1

definition

A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.

DX

19980101

FX

D000068718

HN

98; use SIMVASTATIN (NM) 1986-97

Inverse of AQ

http://purl.bioontology.org/ontology/MESH/Q000032

http://purl.bioontology.org/ontology/MESH/Q000138

http://purl.bioontology.org/ontology/MESH/Q000737

http://purl.bioontology.org/ontology/MESH/Q000493

http://purl.bioontology.org/ontology/MESH/Q000145

http://purl.bioontology.org/ontology/MESH/Q000506

http://purl.bioontology.org/ontology/MESH/Q000819

http://purl.bioontology.org/ontology/MESH/Q000037

http://purl.bioontology.org/ontology/MESH/Q000134

http://purl.bioontology.org/ontology/MESH/Q000592

http://purl.bioontology.org/ontology/MESH/Q000528

http://purl.bioontology.org/ontology/MESH/Q000008

http://purl.bioontology.org/ontology/MESH/Q000031

http://purl.bioontology.org/ontology/MESH/Q000276

http://purl.bioontology.org/ontology/MESH/Q000191

http://purl.bioontology.org/ontology/MESH/Q000633

http://purl.bioontology.org/ontology/MESH/Q000652

http://purl.bioontology.org/ontology/MESH/Q000009

http://purl.bioontology.org/ontology/MESH/Q000302

http://purl.bioontology.org/ontology/MESH/Q000494

http://purl.bioontology.org/ontology/MESH/Q000266

http://purl.bioontology.org/ontology/MESH/Q000600

http://purl.bioontology.org/ontology/MESH/Q000378

http://purl.bioontology.org/ontology/MESH/Q000097

http://purl.bioontology.org/ontology/MESH/Q000627

Inverse of RB

AGG2FN16EV

0

Inverse of RO

http://purl.bioontology.org/ontology/MESH/D000068718

isa

http://purl.bioontology.org/ontology/MESH/D019161

http://purl.bioontology.org/ontology/MESH/D000924

http://purl.bioontology.org/ontology/MESH/D000960

LT

TRD

Machine permutation

98; SIMVASTATIN was indexed under LOVASTATIN/analogs & derivatives 1988-97 & NAPHTHALENES 1986-87

Mapped from

http://purl.bioontology.org/ontology/MESH/C483161

http://purl.bioontology.org/ontology/MESH/C070477

http://purl.bioontology.org/ontology/MESH/C562297

http://purl.bioontology.org/ontology/MESH/C532833

http://purl.bioontology.org/ontology/MESH/C063287

http://purl.bioontology.org/ontology/MESH/C531004

MDA

19970620

MMR

20170117

MN

D02.455.426.559.847.638.400.900

D04.615.638.400.900

notation

D019821

PA

D019161

D000924

D000960

prefLabel

Simvastatin

RR

79902-63-9 (Simvastatin)

TERMUI

T058977

T058975

T058974

T058976

TH

FDA SRS (2014)

USP (19XX)

NLM (1998)

USAN (1987)

BAN (19XX)

INN (19XX)

tui

T109

T121

subClassOf

http://purl.bioontology.org/ontology/MESH/D008148

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http://www.drugbank.ca/drugs/DB00641 FTC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004003 DDO LOOM
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http://purl.bioontology.org/ontology/UATC/C10AA01 ATC LOOM
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http://purl.jp/bio/4/id/200906010113195462 IOBC LOOM
http://purl.jp/bio/4/id/200906010113195462 IOBC LOOM
http://purl.jp/bio/4/id/200906010113195462 IOBC LOOM