loading...| Preferred Name |
Simvastatin |
|
| Synonyms |
MK733 Zocor |
|
| Definitions |
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D019821 |
|
| altLabel |
MK733 MK-733 Synvinolin MK 733 Zocor |
|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
|
| cui |
C4082576 C0733683 C0678181 C0074554 |
|
| DC |
1 |
|
| definition |
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL. |
|
| DX |
19980101 |
|
| FX |
D000068718 |
|
| HN |
98; use SIMVASTATIN (NM) 1986-97 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
0 AGG2FN16EV |
|
| Inverse of RO | ||
| isa |
http://purl.bioontology.org/ontology/MESH/D000960 |
|
| LT |
TRD |
|
| Machine permutation |
98; SIMVASTATIN was indexed under LOVASTATIN/analogs & derivatives 1988-97 & NAPHTHALENES 1986-87 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C070477 http://purl.bioontology.org/ontology/MESH/C483161 http://purl.bioontology.org/ontology/MESH/C063287 http://purl.bioontology.org/ontology/MESH/C532833 |
|
| MDA |
19970620 |
|
| MMR |
20170117 |
|
| MN |
D02.455.426.559.847.638.400.900 D04.615.638.400.900 |
|
| notation |
D019821 |
|
| PA |
D000960 D019161 D000924 |
|
| prefLabel |
Simvastatin |
|
| RR |
79902-63-9 (Simvastatin) |
|
| TERMUI |
T058976 T058975 T058977 T058974 |
|
| TH |
FDA SRS (2014) INN (19XX) NLM (1998) USAN (1987) USP (19XX) BAN (19XX) |
|
| tui |
T109 T121 |
|
| subClassOf |