loading...| Preferred Name |
Lambert-Eaton Myasthenic Syndrome |
|
| Synonyms |
Myasthenic Myopathic Syndrome of Eaton Lambert |
|
| Definitions |
An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471) |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D015624 |
|
| altLabel |
Myasthenic Myopathic Syndrome of Eaton Lambert Eaton-Lambert Myasthenic Syndrome Myopathic-Myasthenic Syndrome of Eaton-Lambert Eaton-Lambert Syndrome Lambert Eaton Syndrome Syndrome, Lambert-Eaton Lambert-Eaton Myasthenic-Myopathic Syndrome Myasthenic Syndrome, Lambert Eaton Eaton Lambert Syndrome Lambert-Eaton Myopathic-Myasthenic Syndrome Myasthenic Myopathic Syndrome of Lambert Eaton Syndrome, Eaton-Lambert Eaton-Lambert Myopathic-Myasthenic Syndrome Myasthenic Syndrome, Eaton-Lambert Lambert-Eaton Myopathic-Myasthenic Syndromes Syndrome, Lambert-Eaton Myasthenic Myasthenic Syndrome, Lambert-Eaton Myasthenic-Myopathic Syndrome of Lambert-Eaton Myopathic Myasthenic Syndrome of Eaton Lambert Syndrome, Eaton-Lambert Myasthenic Eaton-Lambert Myopathic-Myasthenic Syndromes Eaton Lambert Myasthenic Syndrome Myasthenic-Myopathic Syndrome of Eaton-Lambert Lambert-Eaton Syndrome Lambert Eaton Myasthenic Syndrome Myopathic-Myasthenic Syndrome of Lambert-Eaton Lambert-Eaton Myasthenic-Myopathic Syndromes Eaton-Lambert Myasthenic-Myopathic Syndrome |
|
| AQL |
BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI |
|
| cui |
C0022972 |
|
| DC |
1 |
|
| definition |
An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471) |
|
| DX |
19900101 |
|
| HN |
1990 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000178 http://purl.bioontology.org/ontology/MESH/Q000175 http://purl.bioontology.org/ontology/MESH/Q000628 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000139 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000517 http://purl.bioontology.org/ontology/MESH/Q000662 http://purl.bioontology.org/ontology/MESH/Q000469 http://purl.bioontology.org/ontology/MESH/Q000151 http://purl.bioontology.org/ontology/MESH/Q000150 http://purl.bioontology.org/ontology/MESH/Q000821 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000196 http://purl.bioontology.org/ontology/MESH/Q000473 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000382 http://purl.bioontology.org/ontology/MESH/Q000451 http://purl.bioontology.org/ontology/MESH/Q000453 http://purl.bioontology.org/ontology/MESH/Q000534 http://purl.bioontology.org/ontology/MESH/Q000532 http://purl.bioontology.org/ontology/MESH/Q000503 http://purl.bioontology.org/ontology/MESH/Q000188 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000201 http://purl.bioontology.org/ontology/MESH/Q000209 http://purl.bioontology.org/ontology/MESH/Q000208 http://purl.bioontology.org/ontology/MESH/Q000601 http://purl.bioontology.org/ontology/MESH/Q000000981 http://purl.bioontology.org/ontology/MESH/Q000652 |
|
| Machine permutation |
1990 |
|
| MDA |
19890407 |
|
| MMR |
20190222 |
|
| MN |
C04.730.856.490.225 C10.668.758.725.150 C10.114.656.150 C10.574.781.588.225 C20.111.258.500.150 C04.588.614.550.500.225 |
|
| notation |
D015624 |
|
| prefLabel |
Lambert-Eaton Myasthenic Syndrome |
|
| TERMUI |
T046215 T046211 T046213 T368375 T368376 T368377 T046214 T046212 T368374 |
|
| TH |
NLM (2000) NLM (1999) NLM (1990) ORD (2010) |
|
| tui |
T047 |
|
| subClassOf |